Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KLK1 | P06870 | 4/20 | 0.42 |
| ▸ | KLK5 | Q9Y337 | 4/20 | 0.42 |
| ▸ | GCGR | P47871 | 1/20 | 0.39 |
| ▸ | F2 | P00734 | 5/20 | 0.39 |
| ▸ | PLAU | P00749 | 4/20 | 0.39 |
| ▸ | PLAT | P00750 | 4/20 | 0.39 |
| ▸ | F10 | P00742 | 3/20 | 0.39 |
| ▸ | PLG | P00747 | 2/20 | 0.39 |
| ▸ | SIRT2 | Q8IXJ6 | 1/20 | 0.39 |
| ▸ | CA1 | P00915 | 1/20 | 0.38 |
| ▸ | CA2 | P00918 | 1/20 | 0.38 |
| ▸ | MRGPRX1 | Q96LB2 | 1/20 | 0.38 |
| ▸ | NPC1 | O15118 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
| ▸ | HPGD | P15428 | 1/20 | 0.38 |
| ▸ | AGTR1 | P30556 | 1/20 | 0.38 |
| ▸ | RAB9A | P51151 | 1/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.38 |
| ▸ | PRSS1 | P07477 | 4/20 | 0.37 |
| ▸ | PTPN11 | Q06124 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6565256 | 0.89 | AKR1C3 (0.44) | KLK1KLK5F2PLAUPLAT | |
| SCHEMBL6565408 | 0.87 | CNR1 (0.41) | GCGRCA1CA2NPC1ALDH1A1 | |
| SCHEMBL7675063 | 0.87 | F2 (0.48) | KLK1KLK5F2PLAUPLAT | |
| SCHEMBL7677481 | 0.86 | F2 (0.47) | KLK1KLK5F2PLAUPLAT | |
| SCHEMBL6563625 | 0.85 | PRSS1 (0.43) | F2F10MRGPRX1ALDH1A1HPGD | |
| SCHEMBL6563277 | 0.80 | F2 (0.41) | KLK1KLK5F2PLAUPLAT | |
| SCHEMBL7670899 | 0.80 | PRSS1 (0.43) | F2PLAUPLATF10PLG | |
| SCHEMBL7674188 | 0.79 | EGLN1 (0.44) | KLK1KLK5F2PLAUPLAT | |
| SCHEMBL7677130 | 0.78 | PRSS1 (0.41) | KLK1KLK5F2PRSS1PRSS2 | |
| SCHEMBL7670696 | 0.78 | KMT2A (0.44) | KLK1KLK5F2PLATF10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1140802-B1 | SUBSTITUTED ARYL AND HETEROARYL DERIVATIVES, THEIR PRODUCTION AND THEIR USE AS MEDICINES | BOEHRINGER INGELHEIM PHARMA (DE) | 2004-03-17 | — | — | EP | disclosed |
| US-6479524-B1 | TO PROLONG THE THROMBIN TIME | BOEHRINGER INGELHEIM PHARMA KG (DE) | 2002-11-12 | — | — | US | disclosed |
| EP-1140802-A1 | SUBSTITUTED ARYL AND HETEROARYL DERIVATIVES, THEIR PRODUCTION AND THEIR USE AS MEDICINES | BOEHRINGER INGELHEIM KG (DE) | 2001-10-10 | — | — | EP | disclosed |
| WO-2000035859-A1 | SUBSTITUTED ARYL AND HETEROARYL DERIVATIVES, THEIR PRODUCTION AND THEIR USE AS MEDICINES | BOEHRINGER INGELHEIM PHARMA KG (DE) | 2000-06-22 | — | — | WO | disclosed |