Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GAA | P10253 | 1/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.33 |
| ▸ | PTPN11 | Q06124 | 1/20 | 0.33 |
| ▸ | MEN1 | O00255 | 1/20 | 0.31 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.31 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.31 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.31 |
| ▸ | HSP90AB1 | P08238 | 1/20 | 0.31 |
| ▸ | DDB1 | Q16531 | 1/20 | 0.31 |
| ▸ | CRBN | Q96SW2 | 1/20 | 0.31 |
| ▸ | NPC1 | O15118 | 1/20 | 0.31 |
| ▸ | ACACB | O00763 | 1/20 | 0.30 |
| ▸ | JAK1 | P23458 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6565376 | 0.88 | PRSS1 (0.35) | GAASMN1; SMN2KMT2AALDH1A1ACACB | |
| SCHEMBL6565417 | 0.86 | PTPN11 (0.36) | GAAPTPN11ALDH1A1HSP90AA1HSP90AB1 | |
| SCHEMBL6563779 | 0.86 | KCNK3 (0.38) | GAASMN1; SMN2PTPN11MEN1KMT2A | |
| SCHEMBL7676439 | 0.84 | HSD11B1 (0.32) | GAASMN1; SMN2PTPN11MEN1KMT2A | |
| SCHEMBL6565371 | 0.83 | KCNK3 (0.34) | GAASMN1; SMN2PTPN11MEN1KMT2A | |
| SCHEMBL6565533 | 0.82 | ACACB (0.45) | GAAPTPN11MEN1KMT2AALDH1A1 | |
| SCHEMBL6565851 | 0.80 | F2 (0.37) | GAASMN1; SMN2ACACB | |
| SCHEMBL6565336 | 0.80 | ACACB (0.34) | SMN1; SMN2PTPN11KMT2AALDH1A1NPC1 | |
| SCHEMBL6565215 | 0.79 | PIK3CA (0.38) | PTPN11DDB1CRBNACACBJAK1 | |
| SCHEMBL6561835 | 0.79 | PTPN11 (0.35) | GAAPTPN11MEN1KMT2AALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1140802-B1 | SUBSTITUTED ARYL AND HETEROARYL DERIVATIVES, THEIR PRODUCTION AND THEIR USE AS MEDICINES | BOEHRINGER INGELHEIM PHARMA (DE) | 2004-03-17 | — | — | EP | disclosed |
| US-6479524-B1 | TO PROLONG THE THROMBIN TIME | BOEHRINGER INGELHEIM PHARMA KG (DE) | 2002-11-12 | — | — | US | disclosed |