Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MRGPRX4 | Q96LA9 | 2/20 | 0.56 |
| ▸ | NR4A2 | P43354 | 2/20 | 0.56 |
| ▸ | CFD | P00746 | 2/20 | 0.55 |
| ▸ | FFAR1 | O14842 | 6/20 | 0.48 |
| ▸ | FFAR4 | Q5NUL3 | 2/20 | 0.48 |
| ▸ | AKR1B1 | P15121 | 1/20 | 0.48 |
| ▸ | MAOB | P27338 | 1/20 | 0.47 |
| ▸ | PLG | P00747 | 1/20 | 0.46 |
| ▸ | PLAU | P00749 | 1/20 | 0.46 |
| ▸ | F11 | P03951 | 1/20 | 0.46 |
| ▸ | KLKB1 | P03952 | 1/20 | 0.46 |
| ▸ | F7 | P08709 | 1/20 | 0.46 |
| ▸ | TPSB2 | P20231 | 1/20 | 0.46 |
| ▸ | NR1H4 | Q96RI1 | 1/20 | 0.45 |
| ▸ | SMPD1 | P17405 | 1/20 | 0.45 |
| ▸ | F2 | P00734 | 1/20 | 0.45 |
| ▸ | RXRA | P19793 | 1/20 | 0.44 |
| ▸ | NR1H2 | P55055 | 1/20 | 0.44 |
| ▸ | NR1H3 | Q13133 | 1/20 | 0.44 |
| ▸ | ENPP2 | Q13822 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6564604 | 0.94 | MRGPRX4 (0.56) | MRGPRX4NR4A2CFDFFAR1FFAR4 | |
| SCHEMBL6566359 | 0.88 | MRGPRX4 (0.66) | MRGPRX4NR4A2MAOBNR1H4SMPD1 | |
| SCHEMBL6566172 | 0.86 | MRGPRX4 (0.63) | MRGPRX4NR4A2NR1H4SMPD1RXRA | |
| SCHEMBL6887724 | 0.85 | MRGPRX4 (0.53) | MRGPRX4NR4A2MAOBNR1H4SMPD1 | |
| SCHEMBL6883961 | 0.84 | MRGPRX4 (0.55) | MRGPRX4NR4A2MAOBSMPD1RXRA | |
| SCHEMBL6882555 | 0.84 | MRGPRX4 (0.55) | MRGPRX4NR4A2FFAR1MAOBNR1H4 | |
| SCHEMBL6562981 | 0.82 | MRGPRX4 (0.52) | MRGPRX4NR4A2MAOBNR1H4SMPD1 | |
| SCHEMBL3908596 | 0.81 | CFD (0.66) | MRGPRX4NR4A2CFDFFAR1FFAR4 | |
| SCHEMBL6563998 | 0.81 | MRGPRX4 (0.53) | MRGPRX4NR4A2FFAR1FFAR4MAOB | |
| SCHEMBL6883847 | 0.80 | MRGPRX4 (0.47) | MRGPRX4NR4A2FFAR1MAOBNR1H4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6831106-B1 | Selective activity on cell proliferation and differentiation without displaying any hypercalcaemiant nature | GALDERMA RESEARCH & DEVELOPMENT, S.N.C. (FR) | 2004-12-14 | — | — | US | disclosed |
| EP-1235777-B1 | VITAMIN D ANALOGUES | GALDERMA RES & DEV (FR) | 2004-06-16 | — | — | EP | disclosed |
| EP-1235777-A2 | VITAMIN D ANALOGUES | Galderma Research & Development, S.N.C. (FR) | 2002-09-04 | — | — | EP | disclosed |
| WO-2001038303-A2 | VITAMIN D ANALOGUES | GALDERMA RESEARCH & DEVELOPMENT, S.N.C. (FR) | 2001-05-31 | — | — | WO | disclosed |