Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MTNR1B | P49286 | 5/20 | 0.45 |
| ▸ | MTNR1A | P48039 | 4/20 | 0.45 |
| ▸ | AKR1C3 | P42330 | 3/20 | 0.44 |
| ▸ | AKR1C2 | P52895 | 3/20 | 0.44 |
| ▸ | AKR1B10 | O60218 | 2/20 | 0.44 |
| ▸ | AKR1B1 | P15121 | 2/20 | 0.44 |
| ▸ | AKR1C4 | P17516 | 2/20 | 0.44 |
| ▸ | AKR1C1 | Q04828 | 2/20 | 0.44 |
| ▸ | PIN1 | Q13526 | 1/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.43 |
| ▸ | POLB | P06746 | 1/20 | 0.43 |
| ▸ | HPGD | P15428 | 2/20 | 0.43 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.43 |
| ▸ | MAPT | P10636 | 1/20 | 0.43 |
| ▸ | FBP1 | P09467 | 1/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6564101 | 0.92 | SMN1; SMN2 (0.47) | AKR1C3AKR1C2AKR1B10AKR1B1AKR1C4 | |
| SCHEMBL6565266 | 0.90 | SIRT6 (0.45) | AKR1C3AKR1C2AKR1B10AKR1B1AKR1C4 | |
| SCHEMBL6564069 | 0.85 | MEN1 (0.48) | AKR1C3AKR1C2AKR1B1AKR1C4AKR1C1 | |
| SCHEMBL6567226 | 0.81 | KDM4E (0.62) | MTNR1BMTNR1AAKR1C3AKR1C2AKR1B10 | |
| SCHEMBL6566219 | 0.80 | ALDH1A1 (0.41) | AKR1C3AKR1C2AKR1B10AKR1B1AKR1C4 | |
| SCHEMBL8630071 | 0.78 | PIN1 (0.46) | MTNR1BMTNR1AAKR1C3AKR1C2AKR1B10 | |
| SCHEMBL6564212 | 0.78 | MEN1 (0.40) | POLBHPGDTDP1MAPTSMN1; SMN2 | |
| SCHEMBL6566280 | 0.78 | MAPT (0.48) | AKR1C3AKR1C2AKR1C1POLBTDP1 | |
| SCHEMBL6564057 | 0.76 | PLA2G4B (0.49) | MAPTSMN1; SMN2 | |
| SCHEMBL4273530 | 0.75 | SMN1; SMN2 (0.52) | AKR1C3AKR1C2AKR1B10AKR1B1AKR1C4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0765871-B1 | Substituted Quinoline-2-carboxamides, their preparation and their use as prolyle-4-hydroxylase Inhibitors | FIBROGEN INC (US) | 2004-03-31 | — | — | EP | disclosed |
| US-5726305-A | Substituted quinoline-2-carboxamides, their preparation and their use as pharmaceuticals, and intermediates | HOECHST AKTIENGESELLSCHAFT (DE) | 1998-03-10 | — | — | US | disclosed |
| US-5719164-A | Substituted quinoline-2-carboxamides, their preparation and their use as pharmaceuticals, and intermediates | HOECHST AKTIENGESELLSCHAFT (DE) | 1998-02-17 | — | — | US | disclosed |
| EP-0765871-A1 | Substituted Quinoline-2-carboxamides, their preparation and their use as prolyle-4-hydroxylase Inhibitors | HOECHST AKTIENGESELLSCHAFT (DE) | 1997-04-02 | — | — | EP | disclosed |