Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TTR | P02766 | 2/20 | 0.41 |
| ▸ | TSPO | P30536 | 1/20 | 0.40 |
| ▸ | P2RX3 | P56373 | 2/20 | 0.39 |
| ▸ | MIF | P14174 | 1/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.39 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.39 |
| ▸ | EGLN1 | Q9GZT9 | 2/20 | 0.38 |
| ▸ | CTNNB1 | P35222 | 1/20 | 0.38 |
| ▸ | POLB | P06746 | 1/20 | 0.38 |
| ▸ | HSD17B14 | Q9BPX1 | 1/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6564114 | 0.88 | POLB (0.45) | KDM4EHSD17B10POLBMEN1KMT2A | |
| SCHEMBL6566232 | 0.84 | MAPT (0.48) | KDM4EKMT2A | |
| SCHEMBL6567173 | 0.83 | LMNA (0.49) | KDM4EHSD17B10POLBMEN1KMT2A | |
| SCHEMBL6565243 | 0.80 | MCHR1 (0.48) | KDM4EPOLBMEN1KMT2A | |
| SCHEMBL6565264 | 0.76 | MCHR1 (0.51) | MEN1KMT2A | |
| SCHEMBL6567192 | 0.74 | MCHR1 (0.53) | MEN1KMT2A | |
| SCHEMBL6565253 | 0.74 | TDP1 (0.43) | EGLN1KMT2A | |
| SCHEMBL6565245 | 0.74 | DAO (0.41) | KDM4EHSD17B10MEN1KMT2A | |
| SCHEMBL6564103 | 0.74 | MAOB (0.48) | KDM4EMEN1KMT2A | |
| SCHEMBL2975427 | 0.70 | KDM4E (0.56) | KDM4EHSD17B14MEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0765871-B1 | Substituted Quinoline-2-carboxamides, their preparation and their use as prolyle-4-hydroxylase Inhibitors | FIBROGEN INC (US) | 2004-03-31 | — | — | EP | disclosed |
| EP-0765871-A1 | Substituted Quinoline-2-carboxamides, their preparation and their use as prolyle-4-hydroxylase Inhibitors | HOECHST AKTIENGESELLSCHAFT (DE) | 1997-04-02 | — | — | EP | disclosed |