Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 3/20 | 0.48 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.45 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.45 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.45 |
| ▸ | RECQL | P46063 | 1/20 | 0.45 |
| ▸ | ICAM1 | P05362 | 1/20 | 0.43 |
| ▸ | SELE | P16581 | 1/20 | 0.43 |
| ▸ | THRA | P10827 | 1/20 | 0.41 |
| ▸ | THRB | P10828 | 1/20 | 0.41 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.41 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.41 |
| ▸ | ATM | Q13315 | 1/20 | 0.41 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.41 |
| ▸ | GCGR | P47871 | 1/20 | 0.41 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.40 |
| ▸ | HTT | P42858 | 1/20 | 0.40 |
| ▸ | RAB9A | P51151 | 1/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
| ▸ | USP2 | O75604 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6565257 | 0.84 | TTR (0.41) | KDM4EKMT2A | |
| SCHEMBL6564114 | 0.83 | POLB (0.45) | MAPTRECQLCYP3A4NPSR1L3MBTL1 | |
| SCHEMBL6567160 | 0.81 | MAOB (0.47) | MAPTL3MBTL1HTTKDM4EALDH1A1 | |
| SCHEMBL6566230 | 0.81 | MAPT (0.46) | MAPTCYP1A2CYP2C9CYP2C19RECQL | |
| SCHEMBL6567173 | 0.76 | LMNA (0.49) | MAPTCYP1A2CYP2C9CYP2C19RECQL | |
| SCHEMBL22719512 | 0.74 | RXFP1 (0.57) | MAPTCYP1A2CYP2C9CYP2C19RECQL | |
| SCHEMBL6565243 | 0.73 | MCHR1 (0.48) | MAPTCYP1A2CYP2C9CYP2C19RECQL | |
| SCHEMBL28737745 | 0.72 | L3MBTL1 (0.47) | MAPTCYP1A2CYP2C9CYP2C19RECQL | |
| SCHEMBL8941708 | 0.72 | AR (0.54) | MAPTCYP1A2CYP2C9CYP2C19ICAM1 | |
| SCHEMBL6565264 | 0.70 | MCHR1 (0.51) | KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0765871-B1 | Substituted Quinoline-2-carboxamides, their preparation and their use as prolyle-4-hydroxylase Inhibitors | FIBROGEN INC (US) | 2004-03-31 | — | — | EP | disclosed |
| EP-0765871-A1 | Substituted Quinoline-2-carboxamides, their preparation and their use as prolyle-4-hydroxylase Inhibitors | HOECHST AKTIENGESELLSCHAFT (DE) | 1997-04-02 | — | — | EP | disclosed |