Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 2/20 | 0.49 |
| ▸ | RECQL | P46063 | 1/20 | 0.49 |
| ▸ | HPGDS | O60760 | 2/20 | 0.47 |
| ▸ | PDE3B | Q13370 | 1/20 | 0.46 |
| ▸ | PDE3A | Q14432 | 1/20 | 0.46 |
| ▸ | MCHR1 | Q99705 | 1/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 6/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.42 |
| ▸ | MEN1 | O00255 | 4/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.42 |
| ▸ | HPGD | P15428 | 4/20 | 0.42 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.42 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.42 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.42 |
| ▸ | NQO2 | P16083 | 1/20 | 0.42 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.42 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.41 |
| ▸ | MAPT | P10636 | 2/20 | 0.41 |
| ▸ | TP53 | P04637 | 1/20 | 0.41 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6564114 | 0.85 | POLB (0.45) | LMNARECQLMCHR1KMT2AALDH1A1 | |
| SCHEMBL6565243 | 0.84 | MCHR1 (0.48) | LMNARECQLMCHR1KMT2AALDH1A1 | |
| SCHEMBL6565257 | 0.83 | TTR (0.41) | KMT2AMEN1KDM4EHSD17B10POLB | |
| SCHEMBL6565264 | 0.81 | MCHR1 (0.51) | MCHR1KMT2AMEN1TP53 | |
| SCHEMBL6567192 | 0.79 | MCHR1 (0.53) | LMNAMCHR1KMT2AMEN1CYP2C9 | |
| SCHEMBL6565245 | 0.78 | DAO (0.41) | KMT2AALDH1A1MEN1KDM4ENQO2 | |
| SCHEMBL1655885 | 0.76 | MCHR1 (0.56) | LMNAHPGDSPDE3BPDE3AMCHR1 | |
| SCHEMBL6567309 | 0.76 | MRGPRX4 (0.50) | KMT2AALDH1A1MEN1KDM4EHPGD | |
| SCHEMBL6566232 | 0.76 | MAPT (0.48) | RECQLKMT2AALDH1A1KDM4ECYP1A2 | |
| SCHEMBL6079920 | 0.76 | HPGDS (0.47) | LMNAHPGDSPDE3BPDE3AMCHR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0765871-B1 | Substituted Quinoline-2-carboxamides, their preparation and their use as prolyle-4-hydroxylase Inhibitors | FIBROGEN INC (US) | 2004-03-31 | — | — | EP | disclosed |
| EP-0765871-A1 | Substituted Quinoline-2-carboxamides, their preparation and their use as prolyle-4-hydroxylase Inhibitors | HOECHST AKTIENGESELLSCHAFT (DE) | 1997-04-02 | — | — | EP | disclosed |