Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | S1PR4 | O95977 | 4/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.34 |
| ▸ | HPGD | P15428 | 3/20 | 0.34 |
| ▸ | CYP3A4 | P08684 | 3/20 | 0.34 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.34 |
| ▸ | TSHR | P16473 | 2/20 | 0.34 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.34 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.34 |
| ▸ | TXNRD1 | Q16881 | 1/20 | 0.34 |
| ▸ | TXNRD3 | Q86VQ6 | 1/20 | 0.34 |
| ▸ | TXNRD2 | Q9NNW7 | 1/20 | 0.34 |
| ▸ | MEN1 | O00255 | 3/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.34 |
| ▸ | TTR | P02766 | 1/20 | 0.34 |
| ▸ | PPOX | P50336 | 1/20 | 0.34 |
| ▸ | MAPT | P10636 | 5/20 | 0.33 |
| ▸ | NPC1 | O15118 | 3/20 | 0.33 |
| ▸ | LMNA | P02545 | 3/20 | 0.33 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.33 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6566114 | 0.87 | S1PR4 (0.41) | S1PR4ALDH1A1HPGDCYP3A4TDP1 | |
| SCHEMBL6564034 | 0.81 | MEN1 (0.46) | ALDH1A1HPGDCYP3A4TDP1TSHR | |
| SCHEMBL8630500 | 0.79 | HPD (0.43) | S1PR4ALDH1A1CYP3A4TDP1MEN1 | |
| SCHEMBL6567450 | 0.77 | LMNA (0.34) | ALDH1A1HPGDCYP3A4TDP1MEN1 | |
| SCHEMBL27625069 | 0.74 | S1PR4 (0.48) | S1PR4ALDH1A1HPGDCYP3A4KMT2A | |
| SCHEMBL3168592 | 0.74 | S1PR4 (0.51) | S1PR4ALDH1A1HPGDCYP3A4MEN1 | |
| SCHEMBL9508095 | 0.74 | TDP1 (0.47) | ALDH1A1TDP1TSHRMEN1KMT2A | |
| SCHEMBL9732941 | 0.73 | ALDH1A1 (0.46) | S1PR4ALDH1A1HPGDCYP3A4TDP1 | |
| SCHEMBL23909079 | 0.72 | CNR2 (0.41) | S1PR4ALDH1A1MEN1KMT2AMAPT | |
| SCHEMBL9616205 | 0.71 | TDP1 (0.41) | S1PR4ALDH1A1HPGDCYP3A4TDP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0765871-B1 | Substituted Quinoline-2-carboxamides, their preparation and their use as prolyle-4-hydroxylase Inhibitors | FIBROGEN INC (US) | 2004-03-31 | — | — | EP | disclosed |
| EP-0765871-A1 | Substituted Quinoline-2-carboxamides, their preparation and their use as prolyle-4-hydroxylase Inhibitors | HOECHST AKTIENGESELLSCHAFT (DE) | 1997-04-02 | — | — | EP | disclosed |