Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP19A1 | P11511 | 11/20 | 0.61 |
| ▸ | LMNA | P02545 | 3/20 | 0.59 |
| ▸ | NR3C1 | P04150 | 3/20 | 0.59 |
| ▸ | MEN1 | O00255 | 2/20 | 0.59 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.59 |
| ▸ | MAPT | P10636 | 1/20 | 0.59 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.59 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.59 |
| ▸ | AR | P10275 | 3/20 | 0.59 |
| ▸ | SERPINA6 | P08185 | 2/20 | 0.56 |
| ▸ | PGR | P06401 | 2/20 | 0.53 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.53 |
| ▸ | SHBG | P04278 | 2/20 | 0.53 |
| ▸ | ABCC4 | O15439 | 1/20 | 0.53 |
| ▸ | ABCB11 | O95342 | 1/20 | 0.53 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.53 |
| ▸ | ESR1 | P03372 | 1/20 | 0.53 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.53 |
| ▸ | NR3C2 | P08235 | 1/20 | 0.53 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.53 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6566539 | 1.00 | CYP19A1 (0.61) | CYP19A1LMNANR3C1MEN1KMT2A | |
| SCHEMBL11512241 | 0.90 | LMNA (0.74) | CYP19A1LMNANR3C1MEN1KMT2A | |
| SCHEMBL11512237 | 0.90 | LMNA (0.74) | CYP19A1LMNANR3C1MEN1KMT2A | |
| SCHEMBL11600212 | 0.89 | CYP19A1 (0.58) | CYP19A1LMNANR3C1MEN1KMT2A | |
| SCHEMBL11600208 | 0.89 | CYP19A1 (0.58) | CYP19A1LMNANR3C1MEN1KMT2A | |
| SCHEMBL11201705 | 0.89 | CYP19A1 (0.58) | CYP19A1LMNANR3C1MEN1KMT2A | |
| SCHEMBL11125309 | 0.88 | CYP19A1 (0.57) | CYP19A1LMNANR3C1MEN1KMT2A | |
| SCHEMBL11125312 | 0.88 | CYP19A1 (0.57) | CYP19A1LMNANR3C1MEN1KMT2A | |
| SCHEMBL11510735 | 0.84 | LMNA (0.78) | CYP19A1LMNANR3C1MEN1KMT2A | |
| SCHEMBL11510737 | 0.84 | LMNA (0.78) | CYP19A1LMNANR3C1MEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0276393-B1 | PROCESS FOR THE PREPARATION OF 6-ALPHA, 9-ALPHA-DIFLUORO-11-BETA-17-ALPHA-DIHYDROXY-16-ALPHA-METHYL-PREGN-4-ENE-3,20-DIONE AND ITS DERIVATIVES | SCHERING AKTIENGESELLSCHAFT (DE) | 1992-03-04 | — | — | EP | claimed |
| EP-0276393-A2 | Process for the preparation of 6-alpha, 9-alpha-difluoro-11-beta-17-alpha-dihydroxy-16-alpha-methyl-pregn-4-ene-3,20-dione and its derivatives | SCHERING AKTIENGESELLSCHAFT (DE) | 1988-08-03 | — | — | EP | claimed |
| US-6828120-B2 | Preparation of 11 beta ,17 alpha ,21- trihydroxy-6 alpha -methylpregna-1,4-diene-3,20-dione 21-acetate; obtain chemical intermediates, incubate reaction mix and enzymes, recover product | PHARMACIA AND UPJOHN COMPANY | 2004-12-07 | — | — | US | disclosed |
| EP-1399463-A1 | PROCESS TO PREPARE 11$g(b),17$g(a),21-TRIHYDROXY-6$g(a)-METHYLPREGNA-1,4-DIENE-3,20-DIONE 21-ACETATE | PHARMACIA & UPJOHN COMPANY (US) | 2004-03-24 | — | — | EP | disclosed |
| US-20030044885-A1 | Process to prepare 11beta, 17alpha,21-trihydroxy-6alpha-methylpregna-1,4-diene-3,20-dione 21-acetate | CRIA, INC. | 2003-03-06 | — | — | US | disclosed |
| WO-2002102826-A1 | PROCESS TO PREPARE 11β,17α,21-TRIHYDROXY-6α-METHYLPREGNA-1,4-DIENE-3,20-DIONE 21-ACETATE | PHARMACIA & UPJOHN COMPANY (US) | 2002-12-27 | — | — | WO | disclosed |
| EP-0276393-B1 | PROCESS FOR THE PREPARATION OF 6-ALPHA, 9-ALPHA-DIFLUORO-11-BETA-17-ALPHA-DIHYDROXY-16-ALPHA-METHYL-PREGN-4-ENE-3,20-DIONE AND ITS DERIVATIVES | SCHERING AKTIENGESELLSCHAFT (DE) | 1992-03-04 | — | — | EP | disclosed |
| US-4898693-A | Process for production of 6α,9α-difluoro-11β,17α-dihydroxy-16α-methyl-4-pregnene-3,20-dione and its derivatives | SCHERING AKTIENGESELLSCHAFT (DE) | 1990-02-06 | — | — | US | disclosed |
| EP-0276393-A2 | Process for the preparation of 6-alpha, 9-alpha-difluoro-11-beta-17-alpha-dihydroxy-16-alpha-methyl-pregn-4-ene-3,20-dione and its derivatives | SCHERING AKTIENGESELLSCHAFT (DE) | 1988-08-03 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20030044885-A1 | Process to prepare 11beta, 17alpha,21-trihydroxy-6alpha-methylpregna-1,4-diene-3,20-dione 21-acetate | CYP17A1, CYP51A1, HSD17B11 | CYP19A1 5/4885LMNA 1301/4885NR3C1 103/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.