Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | P2RX7 | Q99572 | 2/20 | 0.53 |
| ▸ | LMNA | P02545 | 2/20 | 0.52 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.51 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.51 |
| ▸ | RAB9A | P51151 | 2/20 | 0.47 |
| ▸ | MEN1 | O00255 | 2/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.47 |
| ▸ | NPC1 | O15118 | 1/20 | 0.47 |
| ▸ | HPGD | P15428 | 2/20 | 0.44 |
| ▸ | SIRT5 | Q9NXA8 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.43 |
| ▸ | MAPT | P10636 | 1/20 | 0.43 |
| ▸ | HTT | P42858 | 1/20 | 0.43 |
| ▸ | RECQL | P46063 | 1/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.41 |
| ▸ | ECE1 | P42892 | 1/20 | 0.41 |
| ▸ | P2RX5 | Q93086 | 1/20 | 0.41 |
| ▸ | P2RX4 | Q99571 | 1/20 | 0.41 |
| ▸ | P2RX2 | Q9UBL9 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1947945 | 0.87 | LMNA (0.60) | P2RX7LMNATDP1L3MBTL1RAB9A | |
| SCHEMBL11732481 | 0.75 | LMNA (0.59) | P2RX7LMNATDP1L3MBTL1RAB9A | |
| SCHEMBL6567255 | 0.75 | EPHX2 (0.59) | TDP1L3MBTL1RAB9AMEN1KMT2A | |
| SCHEMBL6567675 | 0.70 | P2RX7 (0.65) | P2RX7MEN1KMT2AP2RX5P2RX4 | |
| SCHEMBL6781078 | 0.69 | LDLR (0.59) | LMNATDP1HPGDALDH1A1MAPT | |
| SCHEMBL10582564 | 0.69 | RAB9A (0.61) | P2RX7LMNATDP1L3MBTL1RAB9A | |
| SCHEMBL1785152 | 0.68 | MEN1 (0.54) | P2RX7LMNATDP1L3MBTL1RAB9A | |
| SCHEMBL1785153 | 0.68 | MEN1 (0.54) | P2RX7LMNATDP1L3MBTL1RAB9A | |
| SCHEMBL16150319 | 0.67 | CYP3A4 (0.66) | RAB9AMEN1KMT2AALDH1A1MAPT | |
| SCHEMBL6568592 | 0.67 | EPHX2 (0.54) | P2RX7P2RX5P2RX4P2RX2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1402887-A1 | New compounds for the inhibition of undesired cell proliferation and use thereof | Jerini AG (DE) | 2004-03-31 | — | — | EP | claimed |
| EP-1402888-A1 | The use of substituted carbocyclic compounds as rotamases inhibitors | Jerini AG (DE) | 2004-03-31 | — | — | EP | claimed |