Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTT | P42858 | 1/20 | 0.54 |
| ▸ | NAMPT | P43490 | 14/20 | 0.53 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.47 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.47 |
| ▸ | MAPT | P10636 | 1/20 | 0.47 |
| ▸ | POLB | P06746 | 2/20 | 0.47 |
| ▸ | MEN1 | O00255 | 1/20 | 0.47 |
| ▸ | RAB9A | P51151 | 1/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6566515 | 0.90 | NAMPT (0.52) | HTTNAMPTROCK2ROCK1MAPT | |
| SCHEMBL6567998 | 0.89 | L3MBTL1 (0.53) | NAMPTMEN1RAB9AKMT2A | |
| SCHEMBL6566625 | 0.87 | PPARA (0.52) | NAMPTMAPTMEN1KMT2A | |
| SCHEMBL6566548 | 0.85 | NPC1 (0.55) | HTTMAPTRAB9AKMT2A | |
| SCHEMBL6566529 | 0.85 | ALDH1A1 (0.56) | HTTNAMPTROCK2ROCK1 | |
| SCHEMBL6568066 | 0.82 | EPHX1 (0.49) | NAMPTROCK2ROCK1MAPTPOLB | |
| SCHEMBL6566630 | 0.82 | PRMT3 (0.46) | NAMPTMEN1RAB9AKMT2A | |
| SCHEMBL6567969 | 0.81 | CASR (0.53) | MEN1KMT2A | |
| SCHEMBL6567876 | 0.81 | RAF1 (0.44) | HTTMAPTMEN1KMT2A | |
| SCHEMBL6567243 | 0.81 | ALDH1A1 (0.53) | HTTMAPTPOLBMEN1RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20040259912-A1 | Benzine derivatives, process for preparing the same and use thereof | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2004-12-23 | — | — | US | disclosed |
| EP-1437344-A1 | BENZENE DERIVATIVES,PROCESS FOR PREPARING THE SAME AND USE THEREOF | Takeda Chemical Industries, Ltd. (JP) | 2004-07-14 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20040259912-A1 | Benzine derivatives, process for preparing the same and use thereof | HRH4, HRH2, HRH1 | HTT 2150/4885NAMPT 3240/4885ROCK2 4403/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.