Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR2A | P28223 | 2/20 | 0.35 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.35 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.35 |
| ▸ | LMNA | P02545 | 1/20 | 0.34 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.34 |
| ▸ | IDO1 | P14902 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8827644 | 0.91 | BCHE (0.42) | — | |
| SCHEMBL6567905 | 0.88 | HTR2A (0.41) | HTR2AL3MBTL1TDP1IDO1 | |
| SCHEMBL8083417 | 0.87 | PRKCI (0.34) | HTR2A | |
| SCHEMBL8083550 | 0.86 | KDM4E (0.38) | ALDH1A1 | |
| SCHEMBL8090038 | 0.84 | ABCB1 (0.39) | HTR2AL3MBTL1TDP1IDO1 | |
| SCHEMBL8091400 | 0.84 | L3MBTL1 (0.44) | L3MBTL1TDP1 | |
| SCHEMBL8090053 | 0.82 | LTA4H (0.40) | HTR2AL3MBTL1 | |
| SCHEMBL7434046 | 0.81 | TDP1 (0.51) | L3MBTL1TDP1ALDH1A1 | |
| SCHEMBL8083504 | 0.80 | TDP1 (0.43) | L3MBTL1TDP1 | |
| SCHEMBL8090170 | 0.78 | TDP1 (0.49) | L3MBTL1TDP1ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6124328-A | TREATING NERVE CELLS WITH A NEUROTROPHIC AGENT; PROMOTING REPAIR OF NEURONAL DAMAGE CAUSED BY DISEASE OR PHYSICAL TRAUMA | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2000-09-26 | — | — | US | disclosed |
| US-6037370-A | TREATING ALZHEIMER*S DISEASE, AMYOTROPHIC LATERAL SCLEROSIS, PARKINSON*S DISEASE, AND OTHER NERVOUS SYSTEM DISORDERS WITH PEPTIDE DERIVATIVES | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2000-03-14 | — | — | US | disclosed |