Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.49 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.48 |
| ▸ | SIGMAR1 | Q99720 | 2/20 | 0.48 |
| ▸ | CALM1 | P0DP23 | 1/20 | 0.47 |
| ▸ | LTA4H | P09960 | 1/20 | 0.47 |
| ▸ | PLAAT3 | P53816 | 1/20 | 0.46 |
| ▸ | PLAAT5 | Q96KN8 | 1/20 | 0.46 |
| ▸ | PLAAT2 | Q9NWW9 | 1/20 | 0.46 |
| ▸ | PLAAT4 | Q9UL19 | 1/20 | 0.46 |
| ▸ | TUBB4A | P04350 | 1/20 | 0.45 |
| ▸ | TUBB | P07437 | 1/20 | 0.45 |
| ▸ | TUBA3C | P0DPH7 | 1/20 | 0.45 |
| ▸ | TUBA1B | P68363 | 1/20 | 0.45 |
| ▸ | TUBA4A | P68366 | 1/20 | 0.45 |
| ▸ | TUBB4B | P68371 | 1/20 | 0.45 |
| ▸ | TUBB3 | Q13509 | 1/20 | 0.45 |
| ▸ | TUBB2A | Q13885 | 1/20 | 0.45 |
| ▸ | TUBB8 | Q3ZCM7 | 1/20 | 0.45 |
| ▸ | TUBA3E | Q6PEY2 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7434046 | 0.97 | TDP1 (0.51) | TDP1L3MBTL1ALDH1A1SIGMAR1CALM1 | |
| SCHEMBL8090038 | 0.93 | ABCB1 (0.39) | TDP1L3MBTL1SIGMAR1ABCB1 | |
| SCHEMBL6567905 | 0.89 | HTR2A (0.41) | TDP1L3MBTL1SIGMAR1 | |
| SCHEMBL8091400 | 0.86 | L3MBTL1 (0.44) | TDP1L3MBTL1SIGMAR1 | |
| SCHEMBL8090053 | 0.84 | LTA4H (0.40) | L3MBTL1SIGMAR1LTA4HMEN1KMT2A | |
| SCHEMBL5632470 | 0.81 | LTA4H (0.69) | TDP1L3MBTL1ALDH1A1SIGMAR1CALM1 | |
| SCHEMBL8091561 | 0.81 | PTGER1 (0.49) | ALDH1A1MEN1KMT2A | |
| SCHEMBL8098123 | 0.80 | MEN1 (0.42) | CALM1LTA4HABCB1ALOX5MEN1 | |
| SCHEMBL8091379 | 0.78 | HTR2A (0.35) | TDP1L3MBTL1ALDH1A1 | |
| SCHEMBL8091559 | 0.78 | TDP1 (0.48) | TDP1L3MBTL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6124328-A | TREATING NERVE CELLS WITH A NEUROTROPHIC AGENT; PROMOTING REPAIR OF NEURONAL DAMAGE CAUSED BY DISEASE OR PHYSICAL TRAUMA | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2000-09-26 | — | — | US | disclosed |
| US-6037370-A | TREATING ALZHEIMER*S DISEASE, AMYOTROPHIC LATERAL SCLEROSIS, PARKINSON*S DISEASE, AND OTHER NERVOUS SYSTEM DISORDERS WITH PEPTIDE DERIVATIVES | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2000-03-14 | — | — | US | disclosed |