Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 2/20 | 0.43 |
| ▸ | MEN1 | O00255 | 3/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.40 |
| ▸ | TK1 | P04183 | 2/20 | 0.40 |
| ▸ | CTSK | P43235 | 2/20 | 0.39 |
| ▸ | KIF11 | P52732 | 1/20 | 0.38 |
| ▸ | POLB | P06746 | 2/20 | 0.37 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.37 |
| ▸ | MAPT | P10636 | 1/20 | 0.37 |
| ▸ | KCNA5 | P22460 | 2/20 | 0.37 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.37 |
| ▸ | GAA | P10253 | 1/20 | 0.36 |
| ▸ | ATM | Q13315 | 1/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.36 |
| ▸ | TSHR | P16473 | 2/20 | 0.36 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.36 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.36 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.36 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.36 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15827068 | 0.82 | MAPT (0.49) | LMNATK1CTSKKIF11MAPT | |
| SCHEMBL6568723 | 0.80 | LMNA (0.39) | LMNAMEN1KMT2ATK1CTSK | |
| SCHEMBL1890756 | 0.79 | HIF1A (0.48) | LMNAMEN1KMT2ATK1CTSK | |
| SCHEMBL2111572 | 0.77 | KIF11 (0.50) | LMNATK1CTSKKIF11MAPT | |
| SCHEMBL9527858 | 0.75 | TK1 (0.40) | TK1CTSKKIF11POLBMAPT | |
| SCHEMBL9527853 | 0.75 | TK1 (0.40) | TK1CTSKKIF11POLBMAPT | |
| SCHEMBL13925696 | 0.75 | PIK3CD (0.40) | LMNAMEN1KMT2APOLBNPSR1 | |
| SCHEMBL19522241 | 0.74 | SLC6A1 (0.44) | MEN1KMT2ATK1KIF11MAPT | |
| SCHEMBL1259261 | 0.74 | HIF1A (0.50) | CTSKPOLBCYP2D6ALDH1A1 | |
| SCHEMBL4771137 | 0.74 | TK1 (0.48) | LMNATK1CTSKKIF11KCNH2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1019361-B1 | POLYFUNCTIONAL CATIONIC CYTOFECTINS, FORMULATIONS AND METHODS FOR GENERATING ACTIVE CYTOFECTIN:POLYNUCLEOTIDE TRANSFECTION COMPLEXES | UNIV CALIFORNIA (US) | 2004-04-14 | — | — | EP | disclosed |
| US-5925623-A | COMPLEXES OF POLYNUCLEOTIDES WITH CATIONIC TRANSPORTER MOLECULES THAT FACILITATE DELIVERY THROUGH MEMBRANE STRUCTURES | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) | 1999-07-20 | — | — | US | disclosed |
| US-5869715-A | Polyfunctional cationic cytofectins | THE REAGENTS OF THE UNIVERSITY OF CALIFORNIA (US) | 1999-02-09 | — | — | US | disclosed |
| US-5824812-A | DRUG DELIVERY WITH AN AMINE SALT OR AMINE QUATERNIZED COMPOUND; CATIONIC TRANSFECTION AMPHIPHILES FOR GENE THERAPY | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) | 1998-10-20 | — | — | US | disclosed |