SCHEMBL6569812

SCHEMBL6569812

CCCCCCCC/C=C\CCCCCCCC(=O)OCC(CN(CCO[Si](c1ccccc1)(c1ccccc1)C(C)(C)C)CCO[Si](c1ccccc1)(c1ccccc1)C(C)(C)C)OC(=O)CCCCCCC/C=C\CCCCCCCC

nearest known ligand 0.55

Predicted protein targets (top 11)

geneUniProtsupporting neighboursconfidence
PRKCA P17252 3/20 0.50
PRKCE Q02156 2/20 0.50
PRKCQ Q04759 2/20 0.50
PRKCD Q05655 2/20 0.50
SELP P16109 1/20 0.46
LPAR1 Q92633 2/20 0.45
ALDH1A1 P00352 1/20 0.45
LMNA P02545 1/20 0.45
DGKA P23743 1/20 0.42
DAGLA Q9Y4D2 1/20 0.41
ENPP2 Q13822 1/20 0.41

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL6336882 0.80 PRKCA (0.58) PRKCAPRKCEPRKCQPRKCDSELP
SCHEMBL6336879 0.80 PRKCA (0.58) PRKCAPRKCEPRKCQPRKCDSELP
SCHEMBL13901298 0.79 ALDH1A1 (0.57) PRKCAPRKCEPRKCQPRKCDLPAR1
SCHEMBL24615029 0.79 PRKCA (0.55) PRKCAPRKCEPRKCQPRKCDSELP
SCHEMBL16520382 0.79 LPAR1 (0.42) PRKCAPRKCEPRKCQPRKCDLPAR1
SCHEMBL6569973 0.79 PRKCA (0.65) PRKCAPRKCEPRKCQPRKCDSELP
SCHEMBL18647043 0.79 ALDH1A1 (0.46) PRKCAPRKCEPRKCQPRKCDLPAR1
SCHEMBL16705778 0.79 DGKA (0.41) LPAR1ALDH1A1DGKA
SCHEMBL16705773 0.78 SOAT2 (0.47) ALDH1A1LMNA
SCHEMBL2133488 0.78 PRKCA (0.67) PRKCAPRKCEPRKCQPRKCDSELP

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1019361-B1 POLYFUNCTIONAL CATIONIC CYTOFECTINS, FORMULATIONS AND METHODS FOR GENERATING ACTIVE CYTOFECTIN:POLYNUCLEOTIDE TRANSFECTION COMPLEXES UNIV CALIFORNIA (US) 2004-04-14 EP disclosed
US-5925623-A COMPLEXES OF POLYNUCLEOTIDES WITH CATIONIC TRANSPORTER MOLECULES THAT FACILITATE DELIVERY THROUGH MEMBRANE STRUCTURES THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) 1999-07-20 US disclosed
US-5869715-A Polyfunctional cationic cytofectins THE REAGENTS OF THE UNIVERSITY OF CALIFORNIA (US) 1999-02-09 US disclosed
US-5824812-A DRUG DELIVERY WITH AN AMINE SALT OR AMINE QUATERNIZED COMPOUND; CATIONIC TRANSFECTION AMPHIPHILES FOR GENE THERAPY THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) 1998-10-20 US disclosed