⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2591449 | 0.88 | GAPDH (0.31) | — | |
| SCHEMBL30502984 | 0.79 | PTGS2 (0.34) | — | |
| SCHEMBL710125 | 0.79 | PTGS2 (0.34) | — | |
| SCHEMBL27800017 | 0.77 | PTGS2 (0.33) | — | |
| SCHEMBL28242714 | 0.73 | PARP11 (0.35) | — | |
| SCHEMBL4847072 | 0.71 | ALDH1A1 (0.42) | — | |
| SCHEMBL25567695 | 0.71 | — | — | |
| SCHEMBL3707104 | 0.70 | CDC25B (0.41) | — | |
| SCHEMBL5310650 | 0.69 | CDC25B (0.40) | — | |
| SCHEMBL7771419 | 0.67 | ALDH1A1 (0.40) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1478613-A2 | SUBSTITUTED 10-ARYL-11H-BENZO[B]FLUORENES AND 7-ARYL-5,6-DIHYDRO-BENZ[A]ANTHRACENES FOR SELECTIVE EFFECTS ON ESTROGEN RECEPTORS | Akzo Nobel N.V. (NL) | 2004-11-24 | — | — | EP | disclosed |
| WO-2003070675-A2 | SUBSTITUTED 10-ARYL-11H-BENZO[B]FLUORENES AND 7-ARYL-5,6-DIHYDRO-BENZO[A]ANTHRACENES FOR SELECTIVE EFFECTS ON ESTROGEN RECEPTORS | AKZO NOBEL N.V. (NL) | 2003-08-28 | — | — | WO | disclosed |
| EP-1313700-A1 | 10-ARYL-11H-BENZO[B]FLUORENE DERIVATIVES AND ANALOGS AS ESTROGENIC COMPOUNDS | Akzo Nobel N.V. (NL) | 2003-05-28 | — | — | EP | disclosed |
| EP-1272471-A1 | NON-STEROIDAL, TETRACYCLIC COMPOUNDS FOR ESTROGEN-RELATED TREATMENTS | Akzo Nobel N.V. (NL) | 2003-01-08 | — | — | EP | disclosed |
| WO-2002016316-A1 | 10-ARYL-11-HBENZO [b]FLUORENE DERIVATIVES AND ANALOGS FOR MEDICINAL USE | AKZO NOBEL N.V. (NL) | 2002-02-28 | — | — | WO | disclosed |
| WO-2001072713-A1 | NON-STEROIDAL, TETRACYCLIC COMPOUNDS FOR ESTROGEN-RELATED TREATMENTS | AKZO NOBEL N.V. (NL) | 2001-10-04 | — | — | WO | disclosed |