Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SIGMAR1 | Q99720 | 4/20 | 0.43 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.41 |
| ▸ | ACHE | P22303 | 3/20 | 0.39 |
| ▸ | TSHR | P16473 | 3/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.37 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.35 |
| ▸ | HKDC1 | Q2TB90 | 1/20 | 0.35 |
| ▸ | MAPT | P10636 | 1/20 | 0.35 |
| ▸ | GRM5 | P41594 | 1/20 | 0.35 |
| ▸ | DPP4 | P27487 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6570118 | 0.84 | MAPK1 (0.42) | SIGMAR1TSHRMEN1KMT2ANPSR1 | |
| SCHEMBL3457922 | 0.70 | L3MBTL3 (0.61) | SIGMAR1TSHRMEN1KMT2ANPSR1 | |
| SCHEMBL12859443 | 0.69 | CYP2D6 (0.70) | SIGMAR1HSP90AA1ACHETSHRMEN1 | |
| SCHEMBL13496661 | 0.67 | SIGMAR1 (0.49) | SIGMAR1HSP90AA1ACHETSHRMEN1 | |
| SCHEMBL13496684 | 0.67 | SIGMAR1 (0.49) | SIGMAR1HSP90AA1ACHETSHRMEN1 | |
| SCHEMBL14375279 | 0.67 | OPRL1 (0.54) | SIGMAR1HSP90AA1ACHETSHRMEN1 | |
| SCHEMBL6570100 | 0.66 | SIGMAR1 (0.51) | SIGMAR1ACHENPSR1ALDH1A1 | |
| SCHEMBL20246717 | 0.65 | SIGMAR1 (0.47) | SIGMAR1HSP90AA1ACHETSHRMEN1 | |
| SCHEMBL4071581 | 0.65 | HKDC1 (0.65) | HKDC1MAPT | |
| SCHEMBL13499239 | 0.64 | SIGMAR1 (0.66) | SIGMAR1ACHEMEN1KMT2AALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1100503-B1 | NON-IMIDAZOLE ALKYLAMINES AS HISTAMINE H 3?-RECEPTOR LIGANDS AND THEIR THERAPEUTIC APPLICATIONS | ILE BIOPROJET SOC CIV (FR) | 2004-09-22 | — | — | EP | claimed |