SCHEMBL6570699

SCHEMBL6570699

COCCNc1ccc(N)c(-c2ccccc2OC)c1

nearest known ligand 0.50

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ALDH1A1 P00352 6/20 0.50
CYP1A2 P05177 5/20 0.50
CYP3A4 P08684 4/20 0.50
CYP2C19 P33261 4/20 0.50
LMNA P02545 2/20 0.50
HSD17B10 Q99714 5/20 0.48
CYP2D6 P10635 2/20 0.48
USP2 O75604 2/20 0.48
ALOX15 P16050 2/20 0.48
CLK4 Q9HAZ1 2/20 0.45
TSHR P16473 2/20 0.45
KDM4E B2RXH2 4/20 0.42
MAPK1 P28482 1/20 0.42
HPGD P15428 1/20 0.42
RAB9A P51151 1/20 0.42
HTR7 P34969 4/20 0.40
KCNH3 Q9ULD8 3/20 0.40
NPC1 O15118 2/20 0.39
MALT1 Q9UDY8 1/20 0.39
ADRB2 P07550 1/20 0.39

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL6573372 0.89 MALT1 (0.42) ALDH1A1CYP1A2CYP3A4CYP2C19LMNA
SCHEMBL6573246 0.86 GAA (0.43) ALDH1A1LMNAHSD17B10TSHRKDM4E
SCHEMBL6573021 0.86 ALDH1A1 (0.40) ALDH1A1CYP1A2CYP3A4CYP2C19LMNA
SCHEMBL6572807 0.85 CYP1A2 (0.49) ALDH1A1CYP1A2CYP3A4CYP2C19HSD17B10
SCHEMBL6573435 0.84 MAPT (0.42) ALDH1A1CYP3A4KDM4EKCNH3TDP1
SCHEMBL6572283 0.84 PTGER4 (0.39) ALDH1A1CYP1A2CYP3A4CYP2C19HSD17B10
SCHEMBL8107830 0.82 GABRG2 (0.38) ALDH1A1CYP1A2CYP3A4CYP2C19LMNA
SCHEMBL6571144 0.82 ADRB2 (0.44) ALDH1A1CYP1A2CYP3A4CYP2C19LMNA
SCHEMBL6574960 0.82 DHFR (0.38) ALDH1A1HSD17B10KDM4ENCF1TDP1
SCHEMBL6574643 0.81 PTGER4 (0.40) ALDH1A1CYP1A2CYP3A4CYP2C19LMNA

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1051143-B1 OXIDIZING HAIR COLORING AGENTS CONTAINING 2,5-DIAMINO-1-PHENYLBENZENE DERIVATIVES AND NOVEL 2,5-DIAMINO-1-PHENYLBENZENE DERIVATIVES WELLA AG (DE) 2004-07-21 EP claimed
EP-1051143-B1 OXIDIZING HAIR COLORING AGENTS CONTAINING 2,5-DIAMINO-1-PHENYLBENZENE DERIVATIVES AND NOVEL 2,5-DIAMINO-1-PHENYLBENZENE DERIVATIVES WELLA AG (DE) 2004-07-21 EP disclosed
US-6500213-B1 Oxidizing hair coloring agents containing 2,5-diamino-1-phenylbenzene derivatives and novel 2,5-diamino-1-phenylbenzene derivatives WELLA AKTIENGESELLSCHAFT (DE) 2002-12-31 US disclosed
EP-1051143-A2 OXIDIZING HAIR COLORING AGENTS CONTAINING 2,5-DIAMINO-1-PHENYLBENZENE DERIVATIVES AND NOVEL 2,5-DIAMINO-1-PHENYLBENZENE DERIVATIVES Wella Aktiengesellschaft (DE) 2000-11-15 EP disclosed
WO-1999059527-A2 OXIDIZING HAIR COLORING AGENTS CONTAINING 2,5-DIAMINO-1-PHENYLBENZENE DERIVATIVES AND NOVEL 2,5-DIAMINO-1-PHENYLBENZENE DERIVATIVES WELLA AKTIENGESELLSCHAFT (DE) 1999-11-25 WO disclosed