Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.63 |
| ▸ | HPGD | P15428 | 1/20 | 0.63 |
| ▸ | TSHR | P16473 | 1/20 | 0.60 |
| ▸ | NPC1 | O15118 | 2/20 | 0.57 |
| ▸ | RAB9A | P51151 | 2/20 | 0.57 |
| ▸ | BACE1 | P56817 | 1/20 | 0.55 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.52 |
| ▸ | ACHE | P22303 | 1/20 | 0.52 |
| ▸ | CES2 | O00748 | 1/20 | 0.51 |
| ▸ | CES1 | P23141 | 1/20 | 0.51 |
| ▸ | MEN1 | O00255 | 1/20 | 0.49 |
| ▸ | PTGIR | P43119 | 1/20 | 0.48 |
| ▸ | PTGES | O14684 | 1/20 | 0.48 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.48 |
| ▸ | TRPM8 | Q7Z2W7 | 1/20 | 0.48 |
| ▸ | HSD17B1 | P14061 | 1/20 | 0.48 |
| ▸ | HSD17B2 | P37059 | 1/20 | 0.48 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.48 |
| ▸ | CA1 | P00915 | 1/20 | 0.47 |
| ▸ | CA2 | P00918 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3659973 | 0.88 | TSHR (0.54) | KDM4EHPGDTSHRNPC1RAB9A | |
| SCHEMBL11311239 | 0.87 | HPGD (0.54) | KDM4EHPGDTSHRNPC1RAB9A | |
| SCHEMBL4001480 | 0.84 | HPGD (0.55) | KDM4EHPGDTSHRNPC1RAB9A | |
| SCHEMBL1926257 | 0.84 | TRPM8 (0.64) | KDM4EHPGDTSHRNPC1RAB9A | |
| SCHEMBL698882 | 0.84 | ADRA2C (0.64) | HPGDTSHRNPC1RAB9AKMT2A | |
| SCHEMBL6569544 | 0.83 | PKM (0.56) | HPGDTSHRNPC1RAB9AKMT2A | |
| SCHEMBL6981124 | 0.82 | KDM4E (0.60) | KDM4EHPGDTSHRNPC1RAB9A | |
| SCHEMBL4560242 | 0.81 | NPC1 (0.60) | KDM4EHPGDTSHRNPC1RAB9A | |
| SCHEMBL9716677 | 0.81 | ADRA2C (0.53) | HPGDTSHRNPC1RAB9AKMT2A | |
| SCHEMBL6783932 | 0.81 | NPC1 (0.70) | KDM4EHPGDTSHRNPC1RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4757066-A | Reduces renal toxicity | SANKYO COMPANY LIMITED (JP) | 1988-07-12 | — | — | US | claimed |
| EP-0838448-B1 | Process for the separation of a mixture of enantiomers | DSM IP ASSETS BV (NL) | 2004-04-21 | — | — | EP | disclosed |
| US-6465684-B2 | DIASTEREOMER COMPLEX OF AT LEAST THREE COMPOUNDS, AT LEAST ONE IS A RESOLVING AGENT IN OPTICALLY ACTIVE FORM, AND AT LEAST ONE IS AN ENANTIOMER IN OPTICALLY ACTIVE FORM; RAPID SEPARATION | DSM N.V. (NL) | 2002-10-15 | — | — | US | disclosed |
| US-20010051747-A1 | Process for the separation of a mixture of enantiomers | DSM N.V. | 2001-12-13 | — | — | US | disclosed |
| US-6235927-B1 | OPTICAL RESOLUTION OF ENANTIOMORPHS OF COMPLEXES | DSM N.V. (NL) | 2001-05-22 | — | — | US | disclosed |
| EP-0838448-A1 | Process for the separation of a mixture of enantiomers | DSM N.V. (NL) | 1998-04-29 | — | — | EP | disclosed |
| EP-0178911-B1 | COMPOSITION CONTAINING A PENEM OR CARBAPENEM ANTIBIOTIC | SANKYO COMPANY LIMITED (JP) | 1992-01-22 | — | — | EP | disclosed |
| US-4757066-A | Reduces renal toxicity | SANKYO COMPANY LIMITED (JP) | 1988-07-12 | — | — | US | disclosed |
| EP-0178911-A2 | Composition containing a penem or carbapenem antibiotic | SANKYO COMPANY LIMITED (JP) | 1986-04-23 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20010051747-A1 | Process for the separation of a mixture of enantiomers | EPHX2, VKORC1, ALDH1A2 | KDM4E 3924/4885HPGD 695/4885TSHR 4265/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.