SCHEMBL6571120

SCHEMBL6571120

Nc1ccc(NCCO)c(-c2ccccc2CBr)c1

nearest known ligand 0.37

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
TOP2B Q02880 1/20 0.37
RECQL P46063 2/20 0.33
KDM4E B2RXH2 3/20 0.33
CYP2C19 P33261 1/20 0.33
CDC25A P30304 1/20 0.33
GLA P06280 1/20 0.33
ALDH1A1 P00352 4/20 0.33
MAPK1 P28482 4/20 0.33
SMN1; SMN2 Q16637 3/20 0.33
NPC1 O15118 2/20 0.33
RAB9A P51151 2/20 0.33
CDK5 Q00535 1/20 0.33
CDK5R1 Q15078 1/20 0.33
TP53 P04637 1/20 0.33
CYP3A4 P08684 1/20 0.33
TSHR P16473 1/20 0.33
TDP1 Q9NUW8 1/20 0.33
PTPRC P08575 2/20 0.32
MEN1 O00255 2/20 0.32
LMNA P02545 2/20 0.32

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL6574155 0.82 ALDH1A1 (0.41) TOP2BRECQLKDM4ECYP2C19CDC25A
SCHEMBL6574189 0.82 NPC1 (0.33) ALDH1A1MAPK1SMN1; SMN2NPC1RAB9A
SCHEMBL6572743 0.81 TOP2B (0.39) TOP2BRECQLKDM4ECYP2C19CDC25A
SCHEMBL6571902 0.80 TOP2B (0.38) TOP2BRECQLKDM4ECYP2C19CDC25A
SCHEMBL6572950 0.80 PLA2G7 (0.50) TOP2BRECQLCYP2C19CDC25AALDH1A1
SCHEMBL6572757 0.80 PLA2G7 (0.43) TOP2BRECQLKDM4ECYP2C19GLA
SCHEMBL6570922 0.79 PTGDR2 (0.44) TOP2BRECQLKDM4ECYP2C19GLA
Hydrochloric Acid SCHEMBL6573152 0.78 PTGDR2 (0.43) TOP2BRECQLKDM4ECYP2C19GLA
SCHEMBL6573315 0.77 KMT2A (0.37) TOP2BRECQLCYP2C19ALDH1A1TSHR
SCHEMBL6573754 0.77 KDM4E (0.40) KDM4EGLAALDH1A1MAPK1NPC1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1051143-B1 OXIDIZING HAIR COLORING AGENTS CONTAINING 2,5-DIAMINO-1-PHENYLBENZENE DERIVATIVES AND NOVEL 2,5-DIAMINO-1-PHENYLBENZENE DERIVATIVES WELLA AG (DE) 2004-07-21 EP claimed
EP-1051143-B1 OXIDIZING HAIR COLORING AGENTS CONTAINING 2,5-DIAMINO-1-PHENYLBENZENE DERIVATIVES AND NOVEL 2,5-DIAMINO-1-PHENYLBENZENE DERIVATIVES WELLA AG (DE) 2004-07-21 EP disclosed
US-6500213-B1 Oxidizing hair coloring agents containing 2,5-diamino-1-phenylbenzene derivatives and novel 2,5-diamino-1-phenylbenzene derivatives WELLA AKTIENGESELLSCHAFT (DE) 2002-12-31 US disclosed
EP-1051143-A2 OXIDIZING HAIR COLORING AGENTS CONTAINING 2,5-DIAMINO-1-PHENYLBENZENE DERIVATIVES AND NOVEL 2,5-DIAMINO-1-PHENYLBENZENE DERIVATIVES Wella Aktiengesellschaft (DE) 2000-11-15 EP disclosed
WO-1999059527-A2 OXIDIZING HAIR COLORING AGENTS CONTAINING 2,5-DIAMINO-1-PHENYLBENZENE DERIVATIVES AND NOVEL 2,5-DIAMINO-1-PHENYLBENZENE DERIVATIVES WELLA AKTIENGESELLSCHAFT (DE) 1999-11-25 WO disclosed