SCHEMBL6572950

SCHEMBL6572950

Nc1ccc(NCCO)c(-c2ccccc2Cl)c1

nearest known ligand 0.50

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
PLA2G7 Q13093 1/20 0.50
ALDH1A1 P00352 1/20 0.41
GAA P10253 1/20 0.41
ALOX15 P16050 1/20 0.41
HTT P42858 1/20 0.41
TDP1 Q9NUW8 1/20 0.41
CDC25A P30304 1/20 0.40
TOP2B Q02880 1/20 0.38
APP P05067 2/20 0.38
BACE1 P56817 2/20 0.38
BACE2 Q9Y5Z0 1/20 0.38
MAPT P10636 2/20 0.37
SMN1; SMN2 Q16637 2/20 0.37
NPC1 O15118 1/20 0.37
TP53 P04637 1/20 0.37
RAB9A P51151 1/20 0.37
DPP4 P27487 1/20 0.37
MAOB P27338 2/20 0.36
MEN1 O00255 1/20 0.36
KMT2A Q03164 1/20 0.36

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL6574155 0.85 ALDH1A1 (0.41) ALDH1A1HTTTDP1CDC25ATOP2B
SCHEMBL6572743 0.84 TOP2B (0.39) ALDH1A1GAAALOX15HTTTDP1
SCHEMBL6571902 0.82 TOP2B (0.38) ALDH1A1HTTTDP1CDC25ATOP2B
SCHEMBL6572757 0.82 PLA2G7 (0.43) PLA2G7ALDH1A1GAAHTTTDP1
SCHEMBL6570922 0.81 PTGDR2 (0.44) ALDH1A1GAAALOX15HTTTDP1
SCHEMBL5162037 0.81 ALDH1A1 (0.46) ALDH1A1GAAALOX15HTTTDP1
SCHEMBL6574529 0.81 PLA2G7 (0.46) PLA2G7ALDH1A1GAAALOX15HTT
Hydrochloric Acid SCHEMBL6573152 0.80 PTGDR2 (0.43) ALDH1A1GAAALOX15HTTTDP1
SCHEMBL6571120 0.80 TOP2B (0.37) ALDH1A1GAAHTTTDP1CDC25A
SCHEMBL6573315 0.80 KMT2A (0.37) ALDH1A1TDP1TOP2BKMT2ACYP2D6

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1051143-B1 OXIDIZING HAIR COLORING AGENTS CONTAINING 2,5-DIAMINO-1-PHENYLBENZENE DERIVATIVES AND NOVEL 2,5-DIAMINO-1-PHENYLBENZENE DERIVATIVES WELLA AG (DE) 2004-07-21 EP claimed
EP-1051143-B1 OXIDIZING HAIR COLORING AGENTS CONTAINING 2,5-DIAMINO-1-PHENYLBENZENE DERIVATIVES AND NOVEL 2,5-DIAMINO-1-PHENYLBENZENE DERIVATIVES WELLA AG (DE) 2004-07-21 EP disclosed
EP-1392637-A2 MODULATORS OF PEROXISOME PROLIFERATOR ACTIVATED RECEPTORS ELI LILLY AND COMPANY (US) 2004-03-03 EP disclosed
US-6500213-B1 Oxidizing hair coloring agents containing 2,5-diamino-1-phenylbenzene derivatives and novel 2,5-diamino-1-phenylbenzene derivatives WELLA AKTIENGESELLSCHAFT (DE) 2002-12-31 US disclosed
WO-2002100813-A2 MODULATORS OF PEROXISOME PROLIFERATOR ACTIVATED RECEPTORS ELI LILLY AND COMPANY (US) 2002-12-19 WO disclosed