SCHEMBL6571350

SCHEMBL6571350

COCCN(CCOC)c1ccc(N)cc1-c1ccccc1C(F)(F)F

nearest known ligand 0.40

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
CYP1A2 P05177 4/20 0.40
CYP2C19 P33261 4/20 0.40
TSHR P16473 3/20 0.40
CYP3A4 P08684 3/20 0.40
ALOX15 P16050 2/20 0.40
HSD17B10 Q99714 2/20 0.40
KDM4E B2RXH2 1/20 0.40
TDP1 Q9NUW8 1/20 0.40
GLA P06280 2/20 0.40
POLB P06746 1/20 0.40
GAA P10253 1/20 0.40
CLK4 Q9HAZ1 3/20 0.37
SLC6A2 P23975 1/20 0.37
SLC6A4 P31645 1/20 0.37
CYP2C9 P11712 1/20 0.37
TRPA1 O75762 2/20 0.37
USP2 O75604 1/20 0.36
ALDH1A1 P00352 1/20 0.36
CYP2D6 P10635 1/20 0.36
MAPK1 P28482 1/20 0.36

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL6574564 0.83 CRHR1 (0.36) TSHRCYP3A4ALOX15HSD17B10TDP1
SCHEMBL6571319 0.83 GLA (0.42) TSHRGLAPOLBGAABACE1
SCHEMBL1927414 0.83 GAA (0.43) TSHRHSD17B10KDM4EGLAPOLB
SCHEMBL6571969 0.82 CRHR1 (0.42) CYP1A2CYP2C19TSHRCYP3A4ALOX15
SCHEMBL6573046 0.81 HTR7 (0.44) CYP1A2CYP2C19TSHRCYP3A4HSD17B10
SCHEMBL6573015 0.81 CRHR1 (0.36) TSHRCYP3A4ALOX15HSD17B10KDM4E
SCHEMBL6570965 0.81 PLA2G7 (0.50) CYP2C19CYP3A4CYP2C9ALDH1A1CRHR1
SCHEMBL6571205 0.79 CRHR1 (0.35) TSHRCYP3A4TDP1GAAALDH1A1
SCHEMBL6570747 0.79 KIF11 (0.41) KDM4EBACE1
SCHEMBL6572343 0.79 CYP1A2 (0.40) CYP1A2CYP2C19TSHRCYP3A4ALOX15

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1051143-B1 OXIDIZING HAIR COLORING AGENTS CONTAINING 2,5-DIAMINO-1-PHENYLBENZENE DERIVATIVES AND NOVEL 2,5-DIAMINO-1-PHENYLBENZENE DERIVATIVES WELLA AG (DE) 2004-07-21 EP claimed
EP-1051143-B1 OXIDIZING HAIR COLORING AGENTS CONTAINING 2,5-DIAMINO-1-PHENYLBENZENE DERIVATIVES AND NOVEL 2,5-DIAMINO-1-PHENYLBENZENE DERIVATIVES WELLA AG (DE) 2004-07-21 EP disclosed
US-6500213-B1 Oxidizing hair coloring agents containing 2,5-diamino-1-phenylbenzene derivatives and novel 2,5-diamino-1-phenylbenzene derivatives WELLA AKTIENGESELLSCHAFT (DE) 2002-12-31 US disclosed
EP-1051143-A2 OXIDIZING HAIR COLORING AGENTS CONTAINING 2,5-DIAMINO-1-PHENYLBENZENE DERIVATIVES AND NOVEL 2,5-DIAMINO-1-PHENYLBENZENE DERIVATIVES Wella Aktiengesellschaft (DE) 2000-11-15 EP disclosed
WO-1999059527-A2 OXIDIZING HAIR COLORING AGENTS CONTAINING 2,5-DIAMINO-1-PHENYLBENZENE DERIVATIVES AND NOVEL 2,5-DIAMINO-1-PHENYLBENZENE DERIVATIVES WELLA AKTIENGESELLSCHAFT (DE) 1999-11-25 WO disclosed