SCHEMBL6572034

SCHEMBL6572034

COc1ccc(C=O)cc1-c1cc(N(CCO)CCO)ccc1N

nearest known ligand 0.42

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ALDH1A1 P00352 10/20 0.42
AOX1 Q06278 1/20 0.42
TSHR P16473 1/20 0.41
FDPS P14324 1/20 0.40
HPGD P15428 2/20 0.39
TRIM24 O15164 1/20 0.39
ALDH5A1 P51649 1/20 0.39
ABAT P80404 1/20 0.39
TDP1 Q9NUW8 1/20 0.39
TRIM33 Q9UPN9 1/20 0.39
L3MBTL1 Q9Y468 1/20 0.38
ESR1 P03372 1/20 0.38
ESR2 Q92731 1/20 0.38
SMN1; SMN2 Q16637 1/20 0.37
KDM4E B2RXH2 1/20 0.37
POLB P06746 2/20 0.36
RXFP1 Q9HBX9 1/20 0.36
MEN1 O00255 1/20 0.36
KMT2A Q03164 1/20 0.36
TTR P02766 1/20 0.35

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL6571343 0.88 FDPS (0.43) ALDH1A1AOX1TSHRFDPSHPGD
SCHEMBL6572855 0.83 ALDH1A1 (0.42) ALDH1A1HPGDMEN1KMT2A
SCHEMBL6572303 0.82 LMNA (0.45) ALDH1A1TSHRHPGDL3MBTL1SMN1; SMN2
SCHEMBL6571857 0.82 GAA (0.40) ALDH1A1TSHRTDP1L3MBTL1SMN1; SMN2
SCHEMBL6572267 0.80 HTR7 (0.41) ALDH1A1TDP1SMN1; SMN2POLBMEN1
SCHEMBL6572756 0.80 ALDH1A1 (0.40) ALDH1A1TSHRALDH5A1ABATTDP1
SCHEMBL6571940 0.79 ALDH1A1 (0.42) ALDH1A1AOX1TSHRFDPSHPGD
SCHEMBL6570985 0.78 HDAC4 (0.37)
SCHEMBL6574718 0.77 ERN1 (0.42) ALDH1A1HPGDTRIM24TRIM33L3MBTL1
SCHEMBL6570789 0.77 ALDH1A1 (0.43) ALDH1A1TRIM24TRIM33L3MBTL1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1051143-B1 OXIDIZING HAIR COLORING AGENTS CONTAINING 2,5-DIAMINO-1-PHENYLBENZENE DERIVATIVES AND NOVEL 2,5-DIAMINO-1-PHENYLBENZENE DERIVATIVES WELLA AG (DE) 2004-07-21 EP claimed
EP-1051143-B1 OXIDIZING HAIR COLORING AGENTS CONTAINING 2,5-DIAMINO-1-PHENYLBENZENE DERIVATIVES AND NOVEL 2,5-DIAMINO-1-PHENYLBENZENE DERIVATIVES WELLA AG (DE) 2004-07-21 EP disclosed
US-6500213-B1 Oxidizing hair coloring agents containing 2,5-diamino-1-phenylbenzene derivatives and novel 2,5-diamino-1-phenylbenzene derivatives WELLA AKTIENGESELLSCHAFT (DE) 2002-12-31 US disclosed
EP-1051143-A2 OXIDIZING HAIR COLORING AGENTS CONTAINING 2,5-DIAMINO-1-PHENYLBENZENE DERIVATIVES AND NOVEL 2,5-DIAMINO-1-PHENYLBENZENE DERIVATIVES Wella Aktiengesellschaft (DE) 2000-11-15 EP disclosed
WO-1999059527-A2 OXIDIZING HAIR COLORING AGENTS CONTAINING 2,5-DIAMINO-1-PHENYLBENZENE DERIVATIVES AND NOVEL 2,5-DIAMINO-1-PHENYLBENZENE DERIVATIVES WELLA AKTIENGESELLSCHAFT (DE) 1999-11-25 WO disclosed