SCHEMBL6571940

SCHEMBL6571940

COc1ccc(C=O)cc1-c1cc(N)ccc1N(CCO)CCO

nearest known ligand 0.42

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ALDH1A1 P00352 7/20 0.42
AOX1 Q06278 1/20 0.42
TRIM24 O15164 1/20 0.42
HPGD P15428 1/20 0.42
ALDH5A1 P51649 1/20 0.42
ABAT P80404 1/20 0.42
TDP1 Q9NUW8 1/20 0.42
TRIM33 Q9UPN9 1/20 0.42
TSHR P16473 1/20 0.41
FDPS P14324 1/20 0.40
ALDH3A1 P30838 3/20 0.38
ALDH1A3 P47895 2/20 0.38
ESR1 P03372 1/20 0.38
ESR2 Q92731 1/20 0.38
SMN1; SMN2 Q16637 1/20 0.37
KDM4E B2RXH2 1/20 0.37
RXFP1 Q9HBX9 1/20 0.36
LCK P06239 1/20 0.36
KDM4C Q9H3R0 1/20 0.36
CYP19A1 P11511 1/20 0.35

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL6574535 0.88 FDPS (0.43) ALDH1A1AOX1TRIM24HPGDALDH5A1
SCHEMBL6572405 0.83 HDAC4 (0.42) ALDH1A1HPGDKDM4ECYP19A1
SCHEMBL6571296 0.82 GAA (0.40) ALDH1A1TDP1TSHRSMN1; SMN2KDM4E
SCHEMBL6570737 0.82 MEN1 (0.47) ALDH1A1HPGDKDM4E
SCHEMBL7891011 0.81 CYP19A1 (0.44) ALDH1A1TSHRSMN1; SMN2KDM4ELCK
SCHEMBL6571978 0.80 HTR7 (0.41) TSHR
SCHEMBL6572307 0.80 ALDH3A1 (0.38) ALDH1A1ALDH5A1ABATALDH3A1ALDH1A3
SCHEMBL6572034 0.79 ALDH1A1 (0.42) ALDH1A1AOX1TRIM24HPGDALDH5A1
SCHEMBL6573059 0.78 HDAC4 (0.40) ALDH1A1HPGDTSHRSMN1; SMN2KDM4E
SCHEMBL6570775 0.77 ERN1 (0.42) ALDH1A1TRIM24TRIM33KDM4ECYP19A1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1051143-B1 OXIDIZING HAIR COLORING AGENTS CONTAINING 2,5-DIAMINO-1-PHENYLBENZENE DERIVATIVES AND NOVEL 2,5-DIAMINO-1-PHENYLBENZENE DERIVATIVES WELLA AG (DE) 2004-07-21 EP claimed
EP-1051143-B1 OXIDIZING HAIR COLORING AGENTS CONTAINING 2,5-DIAMINO-1-PHENYLBENZENE DERIVATIVES AND NOVEL 2,5-DIAMINO-1-PHENYLBENZENE DERIVATIVES WELLA AG (DE) 2004-07-21 EP disclosed
US-6500213-B1 Oxidizing hair coloring agents containing 2,5-diamino-1-phenylbenzene derivatives and novel 2,5-diamino-1-phenylbenzene derivatives WELLA AKTIENGESELLSCHAFT (DE) 2002-12-31 US disclosed
EP-1051143-A2 OXIDIZING HAIR COLORING AGENTS CONTAINING 2,5-DIAMINO-1-PHENYLBENZENE DERIVATIVES AND NOVEL 2,5-DIAMINO-1-PHENYLBENZENE DERIVATIVES Wella Aktiengesellschaft (DE) 2000-11-15 EP disclosed
WO-1999059527-A2 OXIDIZING HAIR COLORING AGENTS CONTAINING 2,5-DIAMINO-1-PHENYLBENZENE DERIVATIVES AND NOVEL 2,5-DIAMINO-1-PHENYLBENZENE DERIVATIVES WELLA AKTIENGESELLSCHAFT (DE) 1999-11-25 WO disclosed