SCHEMBL6572709

SCHEMBL6572709

CNc1ccc(N)c(-c2ccc(O)cc2O)c1

nearest known ligand 0.41

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ALDH1A1 P00352 2/20 0.41
CYP3A4 P08684 2/20 0.41
THRB P10828 2/20 0.41
ALOX15 P16050 2/20 0.41
RECQL P46063 2/20 0.41
HIF1A Q16665 2/20 0.41
TDP1 Q9NUW8 1/20 0.41
TP53 P04637 1/20 0.39
HPGD P15428 1/20 0.39
CASP1 P29466 1/20 0.39
HSD17B10 Q99714 1/20 0.39
HSP90AA1 P07900 1/20 0.38
HSP90AB1 P08238 1/20 0.38
APP P05067 8/20 0.38
TYR P14679 1/20 0.37
ALOX5 P09917 1/20 0.36
AMY1A P0DUB6 1/20 0.35
SNCA P37840 1/20 0.35
ESR1 P03372 1/20 0.34
MAPT P10636 1/20 0.34

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL6571996 0.91 ALDH1A1 (0.44) ALDH1A1CYP3A4THRBALOX15RECQL
SCHEMBL6571922 0.86 TSHR (0.41) ALDH1A1CYP3A4THRBALOX15RECQL
SCHEMBL6571392 0.83 PDK2 (0.39) ALDH1A1CYP3A4THRBALOX15RECQL
SCHEMBL6571412 0.81 APP (0.47) ALDH1A1CYP3A4THRBALOX15RECQL
SCHEMBL6570909 0.78 PDE10A (0.44) ALDH1A1CYP3A4THRBALOX15RECQL
SCHEMBL6572457 0.78 ALOX5 (0.36) ALDH1A1CYP3A4THRBALOX15RECQL
SCHEMBL6572762 0.77 CYP3A4 (0.39) ALDH1A1CYP3A4THRBALOX15RECQL
SCHEMBL6572177 0.77 HSD17B1 (0.41) ALDH1A1CYP3A4TDP1APPCA12
SCHEMBL6570977 0.76 PTGER4 (0.39) ALDH1A1CYP3A4THRBALOX15RECQL
SCHEMBL6570907 0.76 HTR6 (0.37) ALDH1A1CYP3A4THRBALOX15RECQL

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1051143-B1 OXIDIZING HAIR COLORING AGENTS CONTAINING 2,5-DIAMINO-1-PHENYLBENZENE DERIVATIVES AND NOVEL 2,5-DIAMINO-1-PHENYLBENZENE DERIVATIVES WELLA AG (DE) 2004-07-21 EP claimed
EP-1051143-B1 OXIDIZING HAIR COLORING AGENTS CONTAINING 2,5-DIAMINO-1-PHENYLBENZENE DERIVATIVES AND NOVEL 2,5-DIAMINO-1-PHENYLBENZENE DERIVATIVES WELLA AG (DE) 2004-07-21 EP disclosed
US-6500213-B1 Oxidizing hair coloring agents containing 2,5-diamino-1-phenylbenzene derivatives and novel 2,5-diamino-1-phenylbenzene derivatives WELLA AKTIENGESELLSCHAFT (DE) 2002-12-31 US disclosed
EP-1051143-A2 OXIDIZING HAIR COLORING AGENTS CONTAINING 2,5-DIAMINO-1-PHENYLBENZENE DERIVATIVES AND NOVEL 2,5-DIAMINO-1-PHENYLBENZENE DERIVATIVES Wella Aktiengesellschaft (DE) 2000-11-15 EP disclosed
WO-1999059527-A2 OXIDIZING HAIR COLORING AGENTS CONTAINING 2,5-DIAMINO-1-PHENYLBENZENE DERIVATIVES AND NOVEL 2,5-DIAMINO-1-PHENYLBENZENE DERIVATIVES WELLA AKTIENGESELLSCHAFT (DE) 1999-11-25 WO disclosed