SCHEMBL6574247

SCHEMBL6574247

CN(CCOc1ccc(N)cc1-n1cccc1)CCc1ccc(N)cc1

nearest known ligand 0.42

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
SIGMAR1 Q99720 2/20 0.42
KCNH2 Q12809 6/20 0.42
CYP1A2 P05177 1/20 0.39
CYP3A4 P08684 1/20 0.39
CYP2D6 P10635 1/20 0.39
BLM P54132 1/20 0.38
PMP22 Q01453 1/20 0.38
SMPD1 P17405 6/20 0.38
CACNA1F O60840 1/20 0.36
CHRM2 P08172 1/20 0.36
ACHE P22303 1/20 0.36
AGTR1 P30556 1/20 0.36
DRD3 P35462 1/20 0.36
CACNA1D Q01668 1/20 0.36
CACNA1S Q13698 1/20 0.36
CACNA1C Q13936 1/20 0.36
CYP19A1 P11511 1/20 0.36
MEN1 O00255 1/20 0.36
KMT2A Q03164 1/20 0.36
CYBB P04839 1/20 0.35

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL6573552 0.90 CYP1A2 (0.55) KCNH2CYP1A2CYP3A4CYP2D6BLM
SCHEMBL6572919 0.79 KCNH2 (0.61) SIGMAR1KCNH2BLMCYP19A1MEN1
SCHEMBL6572758 0.77 KCNH2 (0.62) KCNH2CYP1A2CYP3A4CYP2D6CACNA1F
SCHEMBL7698337 0.75 KCNH2 (0.51) SIGMAR1KCNH2CACNA1FCHRM2ACHE
SCHEMBL7024969 0.73 KCNH2 (0.73) SIGMAR1KCNH2CACNA1FCHRM2ACHE
SCHEMBL24600583 0.73 KCNH2 (0.46) SIGMAR1KCNH2CYP1A2CYP3A4CYP2D6
SCHEMBL6574500 0.73 KCNH2 (0.50) SIGMAR1KCNH2CYP1A2CYP3A4CYP2D6
SCHEMBL6572210 0.71 KCNH2 (0.72) KCNH2CYP1A2CYP3A4CYP2D6BLM
Hydrochloric Acid SCHEMBL6574476 0.71 KCNH2 (0.70) KCNH2CYP1A2CYP3A4CYP2D6BLM
SCHEMBL9627913 0.71 SIGMAR1 (0.66) SIGMAR1KCNH2CYP1A2CYP3A4CYP2D6

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0775689-B9 NOVEL AMINE DERIVATIVE, PROCESS FOR PRODUCING THE SAME, AND USE THEREOF AS ANTIARRHYTHMIC C & C RES LABS (KR) 2004-09-15 EP disclosed
EP-0775689-B1 NOVEL AMINE DERIVATIVE, PROCESS FOR PRODUCING THE SAME, AND USE THEREOF AS ANTIARRHYTHMIC C & C RES LABS (KR) 2003-09-03 EP disclosed
US-6057358-A POTASSIUM CHANNEL BLOCKING ANTIARRHYTHMIC DRUGS WITH LESS SIDE EFFECTS C&C RESEARCH LABS. (KR) 2000-05-02 US disclosed
EP-0775689-A1 NOVEL AMINE DERIVATIVE, PROCESS FOR PRODUCING THE SAME, AND USE THEREOF AS ANTIARRHYTHMIC C & C RESEARCH LABS. (KR) 1997-05-28 EP disclosed