Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PARP1 | P09874 | 1/20 | 0.55 |
| ▸ | AURKA | O14965 | 1/20 | 0.48 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.47 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.47 |
| ▸ | NR1I2 | O75469 | 1/20 | 0.47 |
| ▸ | VDR | P11473 | 1/20 | 0.47 |
| ▸ | CYP2B6 | P20813 | 1/20 | 0.47 |
| ▸ | AHR | P35869 | 1/20 | 0.47 |
| ▸ | NR1I3 | Q14994 | 1/20 | 0.47 |
| ▸ | PIN1 | Q13526 | 1/20 | 0.47 |
| ▸ | SLC9A1 | P19634 | 1/20 | 0.47 |
| ▸ | DHODH | Q02127 | 3/20 | 0.45 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.45 |
| ▸ | MEN1 | O00255 | 2/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.45 |
| ▸ | USP2 | O75604 | 1/20 | 0.45 |
| ▸ | MAPT | P10636 | 1/20 | 0.45 |
| ▸ | TSHR | P16473 | 1/20 | 0.45 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.45 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6575637 | 0.88 | PARP1 (0.40) | PARP1SLC9A1DHODHKDM4EMEN1 | |
| SCHEMBL6576423 | 0.88 | CYP1A2 (0.45) | PARP1CYP1A2CYP2C9DHODHKDM4E | |
| SCHEMBL6576417 | 0.87 | PARP1 (0.48) | PARP1AURKAKDM4EMEN1KMT2A | |
| SCHEMBL6575742 | 0.83 | HDAC6 (0.63) | PARP1CYP1A2CYP2C9DHODHMEN1 | |
| Bisdisulizole SCHEMBL29507102 | 0.81 | HDAC6 (0.52) | PARP1CYP2C9DHODHKDM4EMEN1 | |
| Bisdisulizole SCHEMBL62139 | 0.81 | HDAC6 (0.52) | PARP1CYP2C9DHODHKDM4EMEN1 | |
| Bisdisulizole SCHEMBL29507075 | 0.81 | HDAC6 (0.52) | PARP1CYP2C9DHODHKDM4EMEN1 | |
| SCHEMBL6575734 | 0.81 | HDAC6 (0.48) | CYP2C9DHODHHDAC6CYP3A4CYP2C19 | |
| Bisdisulizole SCHEMBL1830829 | 0.80 | HDAC6 (0.51) | PARP1CYP2C9DHODHKDM4EMEN1 | |
| Bisdisulizole SCHEMBL4777834 | 0.80 | HDAC6 (0.51) | PARP1CYP2C9DHODHKDM4EMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1167358-B1 | 2-Phenylbenzimidazole sulphonic acids as UV-B filters | MERCK PATENT GMBH (DE) | 2004-09-15 | — | — | EP | disclosed |
| EP-1167359-B1 | Process for the preparation of 2-arylbenzimidazole sulphonic acids | MERCK PATENT GMBH (DE) | 2004-04-28 | — | — | EP | disclosed |
| US-6593476-B2 | Using 2-arylbenzimidazolesulfonic acid | MERCK Patent Gesellschaft mit beschränkter Haftung (DE) | 2003-07-15 | — | — | US | disclosed |
| US-6440401-B1 | 2-PHENYLBENZIMIDAZOLEDI- AND TRISULFONIC ACIDS; COSMETIC FORMULATIONS | MERCK PATENT GESELLSCHAFT MIT BESCHRAENKTER HAFTUNG (DE) | 2002-08-27 | — | — | US | disclosed |
| US-20020055532-A1 | UV-B filter | MERCK PATENT GESELLSCHAFT (DE) | 2002-05-09 | — | — | US | disclosed |
| US-20020016349-A1 | UV-B filters | MERCK PATENT GESELLSCHAFT (DE) | 2002-02-07 | — | — | US | disclosed |
| US-20020013474-A1 | Process for the preparation of UV filter substances | MERCK PATENT GESELLSCHAFT | 2002-01-31 | — | — | US | disclosed |
| EP-1167358-A1 | 2-Phenylbenzimidazole sulphonic acids as UV-B filters | MERCK PATENT GmbH (DE) | 2002-01-02 | — | — | EP | disclosed |
| EP-1167359-A1 | Process for the preparation of 2-arylbenzimidazole sulphonic acids and their use as UV-filters | MERCK PATENT GmbH (DE) | 2002-01-02 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20020055532-A1 | UV-B filter | CBR1, UQCRB, H1-0 | PARP1 1843/4885AURKA 4655/4885CYP1A2 187/4885 |
| US-20020013474-A1 | Process for the preparation of UV filter substances | AOX1, CYP1A1, AOC2 | PARP1 666/4885AURKA 2249/4885CYP1A2 34/4885 |
| US-20020016349-A1 | UV-B filters | CBR1, H1-0, CYP1B1 | PARP1 1798/4885AURKA 4693/4885CYP1A2 211/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.