Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GABRA1 | P14867 | 1/20 | 0.51 |
| ▸ | GABRB1 | P18505 | 1/20 | 0.51 |
| ▸ | EYA3 | Q99504 | 10/20 | 0.48 |
| ▸ | CYP2C19 | P33261 | 6/20 | 0.47 |
| ▸ | CYP2C9 | P11712 | 5/20 | 0.44 |
| ▸ | TTR | P02766 | 3/20 | 0.44 |
| ▸ | MEN1 | O00255 | 2/20 | 0.44 |
| ▸ | ABCB11 | O95342 | 2/20 | 0.44 |
| ▸ | LMNA | P02545 | 2/20 | 0.44 |
| ▸ | PGR | P06401 | 2/20 | 0.44 |
| ▸ | ADRA2A | P08913 | 2/20 | 0.44 |
| ▸ | TBXA2R | P21731 | 2/20 | 0.44 |
| ▸ | OPRM1 | P35372 | 2/20 | 0.44 |
| ▸ | SLC6A3 | Q01959 | 2/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.44 |
| ▸ | BIRC5 | O15392 | 1/20 | 0.44 |
| ▸ | HTR1A | P08908 | 1/20 | 0.44 |
| ▸ | DRD1 | P21728 | 1/20 | 0.44 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.44 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6490125 | 0.82 | EYA3 (0.69) | GABRA1GABRB1EYA3CYP2C19CYP2C9 | |
| SCHEMBL6737999 | 0.79 | EYA3 (0.71) | GABRA1GABRB1EYA3CYP2C19CYP2C9 | |
| SCHEMBL6573415 | 0.77 | NQO1 (0.41) | GABRA1GABRB1CYP2C19CYP2C9MEN1 | |
| SCHEMBL6480569 | 0.69 | CYP2C19 (0.61) | EYA3CYP2C19CYP2C9POLBTHRB | |
| SCHEMBL29405385 | 0.69 | GABRA1 (1.00) | GABRA1GABRB1LMNAKMT2APTGS1 | |
| SCHEMBL2414208 | 0.69 | GABRA1 (0.64) | GABRA1GABRB1LMNABCL2MCL1 | |
| SCHEMBL15698033 | 0.68 | EYA3 (0.83) | EYA3CYP2C19CYP2C9TTRMEN1 | |
| SCHEMBL28078271 | 0.68 | GABRA1 (0.78) | GABRA1GABRB1LMNAPTGS1SLC6A2 | |
| SCHEMBL8082189 | 0.67 | GABRA1 (0.60) | GABRA1GABRB1CYP2C19LMNACYP1A2 | |
| SCHEMBL11326985 | 0.66 | GABRA1 (0.68) | GABRA1GABRB1CYP2C19MEN1LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1408958-A1 | BENZOFURANES AND THEIR USE IN THE TREATMENT OF ATRIAL FIBRILLATION | KARO BIO AB (SE) | 2004-04-21 | — | — | EP | disclosed |
| WO-2003009839-A1 | BENZOFURANES AND THEIR USE IN THE TREATMENT OF ATRIAL FIBRILLATION | KARO BIO AB (SE) | 2003-02-06 | — | — | WO | disclosed |