Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR1A | P08908 | 4/20 | 0.45 |
| ▸ | HTR1D | P28221 | 1/20 | 0.45 |
| ▸ | HTR1B | P28222 | 1/20 | 0.45 |
| ▸ | MAPT | P10636 | 2/20 | 0.45 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.44 |
| ▸ | LMNA | P02545 | 1/20 | 0.44 |
| ▸ | HTT | P42858 | 1/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.44 |
| ▸ | NCF1 | P14598 | 7/20 | 0.44 |
| ▸ | CYBB | P04839 | 2/20 | 0.43 |
| ▸ | NOX5 | Q96PH1 | 1/20 | 0.43 |
| ▸ | NR3C1 | P04150 | 1/20 | 0.43 |
| ▸ | SLC6A4 | P31645 | 3/20 | 0.42 |
| ▸ | MEN1 | O00255 | 1/20 | 0.42 |
| ▸ | NPC1 | O15118 | 1/20 | 0.42 |
| ▸ | POLB | P06746 | 1/20 | 0.42 |
| ▸ | HPGD | P15428 | 1/20 | 0.42 |
| ▸ | RAB9A | P51151 | 1/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8068790 | 0.93 | ALDH1A1 (0.48) | HTR1AHTR1DHTR1BMAPTKDM4E | |
| SCHEMBL8058421 | 0.92 | NCF1 (0.50) | HTR1AHTR1DHTR1BMAPTKDM4E | |
| SCHEMBL23412378 | 0.89 | MAPT (0.52) | HTR1AHTR1DHTR1BMAPTKDM4E | |
| SCHEMBL23412188 | 0.87 | NCF1 (0.51) | HTR1AHTR1DHTR1BMAPTKDM4E | |
| SCHEMBL27958848 | 0.86 | KDM4E (0.48) | HTR1AHTR1DHTR1BMAPTKDM4E | |
| SCHEMBL23412437 | 0.86 | NCF1 (0.58) | HTR1AHTR1DHTR1BMAPTKDM4E | |
| SCHEMBL23412286 | 0.84 | NCF1 (0.59) | MAPTKDM4ENCF1CYBBNOX5 | |
| SCHEMBL23412394 | 0.84 | NCF1 (0.59) | MAPTKDM4ENCF1CYBBNOX5 | |
| SCHEMBL23412668 | 0.84 | NCF1 (0.59) | MAPTKDM4ENCF1CYBBNOX5 | |
| SCHEMBL5211140 | 0.83 | HTR1A (0.45) | HTR1AHTR1DHTR1BMAPTKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 11 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-100408575-C | Aryl-8-azabicyclo[3,2,1]octanes for treating depression | WYETH CORP (US) | 2008-08-06 | — | — | CN | disclosed |
| EP-1390364-B1 | ARYL-8-AZABICYCLO 3.2.1]OCTANES FOR THE TREATMENT OF DEPRESSION | WYETH CORP (US) | 2004-09-29 | — | — | EP | disclosed |
| CN-1509287-A | Aryl-8-azabicyclo[3,2,1]octanes for treating depression | — | 2004-06-30 | — | — | CN | disclosed |
| EP-1390364-A1 | ARYL-8-AZABICYCLO 3.2.1]OCTANES FOR THE TREATMENT OF DEPRESSION | Wyeth (US) | 2004-02-25 | — | — | EP | disclosed |
| US-6632824-B2 | Have the ability to act at the 5-HT transporter. | WYETH | 2003-10-14 | — | — | US | disclosed |
| US-20030032645-A1 | Aryl-8-azabicyclo [3.2.1] octanes for the treatment of depression | WYETH | 2003-02-13 | — | — | US | disclosed |
| WO-2002096906-A1 | ARYL-8-AZABICYCLO[3.2.1]OCTANES FOR THE TREATMENT OF DEPRESSION | WYETH (US) | 2002-12-05 | — | — | WO | disclosed |
| CN-1348451-A | Azaindole derivatives for the treatment of depression | AMERICAN HOME PROD (US) | 2002-05-08 | — | — | CN | disclosed |
| EP-1171439-A1 | AZAINDOLE DERIVATIVES FOR THE TREATMENT OF DEPRESSION | AMERICAN HOME PRODUCTS CORPORATION (US) | 2002-01-16 | — | — | EP | disclosed |
| US-6337336-B1 | HETEROCYCLIC OXYPHENOL COMPOUNDS | AMERICAN HOME PRODUCTS CORPORATION | 2002-01-08 | — | — | US | disclosed |
| WO-2000064898-A1 | AZAINDOLE DERIVATIVES FOR THE TREATMENT OF DEPRESSION | AMERICAN HOME PRODUCTS CORPORATION (US) | 2000-11-02 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20030032645-A1 | Aryl-8-azabicyclo [3.2.1] octanes for the treatment of depression | HTR1A, HTR1D, HTR2C | HTR1A 1/4885HTR1D 2/4885HTR1B 5/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.