Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MMP8 | P22894 | 9/20 | 0.60 |
| ▸ | MMP2 | P08253 | 6/20 | 0.60 |
| ▸ | MMP9 | P14780 | 6/20 | 0.60 |
| ▸ | MMP1 | P03956 | 6/20 | 0.57 |
| ▸ | MMP3 | P08254 | 5/20 | 0.57 |
| ▸ | TSHR | P16473 | 3/20 | 0.45 |
| ▸ | HPGD | P15428 | 1/20 | 0.45 |
| ▸ | MMP7 | P09237 | 1/20 | 0.42 |
| ▸ | MMP12 | P39900 | 1/20 | 0.42 |
| ▸ | MMP13 | P45452 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.42 |
| ▸ | MAPT | P10636 | 1/20 | 0.42 |
| ▸ | FKBP1A | P62942 | 1/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | GAA | P10253 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6578656 | 0.88 | MMP2 (0.54) | MMP8MMP2MMP9MMP1MMP3 | |
| SCHEMBL6578384 | 0.85 | HPGD (0.44) | MMP8MMP2MMP9TSHRHPGD | |
| SCHEMBL6578655 | 0.76 | MMP2 (0.53) | MMP8MMP2MMP9MMP1MMP3 | |
| SCHEMBL5196301 | 0.75 | HDAC3 (0.63) | MMP8MMP2MMP9MMP1MMP3 | |
| SCHEMBL6575904 | 0.74 | MMP1 (0.55) | MMP8MMP2MMP9MMP1MMP3 | |
| SCHEMBL7333389 | 0.74 | CYP1A2 (0.54) | TSHRHPGDALDH1A1MEN1KMT2A | |
| SCHEMBL6578119 | 0.74 | MMP2 (0.56) | MMP8MMP2MMP9MMP1MMP3 | |
| SCHEMBL3266606 | 0.72 | HTT (0.48) | MMP8MMP2MMP9MMP1MMP3 | |
| SCHEMBL6806277 | 0.71 | MMP7 (0.52) | MMP8MMP2MMP9MMP1MMP3 | |
| SCHEMBL6578667 | 0.71 | STS (0.51) | MMP8MMP2MMP9MMP1MMP3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0968182-B1 | HYDROXAMIC AND CARBOXYLIC ACID DERIVATIVES HAVING MMP AND TNF INHIBITORY ACTIVITY | DARWIN DISCOVERY LTD (GB) | 2004-05-06 | — | — | EP | claimed |