Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MMP2 | P08253 | 5/20 | 0.53 |
| ▸ | MMP9 | P14780 | 5/20 | 0.53 |
| ▸ | MMP8 | P22894 | 5/20 | 0.53 |
| ▸ | MMP1 | P03956 | 4/20 | 0.52 |
| ▸ | MMP3 | P08254 | 4/20 | 0.52 |
| ▸ | HTR2A | P28223 | 2/20 | 0.46 |
| ▸ | HDAC8 | Q9BY41 | 5/20 | 0.44 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.43 |
| ▸ | HDAC3 | O15379 | 4/20 | 0.43 |
| ▸ | HDAC4 | P56524 | 4/20 | 0.43 |
| ▸ | HDAC1 | Q13547 | 4/20 | 0.43 |
| ▸ | HDAC7 | Q8WUI4 | 4/20 | 0.43 |
| ▸ | HDAC2 | Q92769 | 4/20 | 0.43 |
| ▸ | HDAC10 | Q969S8 | 4/20 | 0.43 |
| ▸ | HDAC11 | Q96DB2 | 4/20 | 0.43 |
| ▸ | HDAC6 | Q9UBN7 | 4/20 | 0.43 |
| ▸ | HDAC9 | Q9UKV0 | 4/20 | 0.43 |
| ▸ | HDAC5 | Q9UQL6 | 4/20 | 0.43 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.42 |
| ▸ | NPFFR2 | Q9Y5X5 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6578081 | 0.92 | MMP2 (0.48) | MMP2MMP9MMP8MMP1MMP3 | |
| SCHEMBL6580383 | 0.89 | HTR2A (0.50) | MMP2MMP9MMP8MMP1MMP3 | |
| SCHEMBL6575904 | 0.86 | MMP1 (0.55) | MMP2MMP9MMP8MMP1MMP3 | |
| SCHEMBL6578119 | 0.84 | MMP2 (0.56) | MMP2MMP9MMP8MMP1MMP3 | |
| SCHEMBL6578667 | 0.82 | STS (0.51) | MMP2MMP9MMP8MMP1MMP3 | |
| SCHEMBL6578658 | 0.81 | THRB (0.48) | HTR2A | |
| Trifluoroacetic Acid SCHEMBL6578085 | 0.79 | MMP2 (0.51) | MMP2MMP9MMP8MMP1MMP3 | |
| SCHEMBL13938131 | 0.77 | SIGMAR1 (0.61) | SIGMAR1 | |
| SCHEMBL6575901 | 0.76 | MMP8 (0.60) | MMP2MMP9MMP8MMP1MMP3 | |
| SCHEMBL7079165 | 0.75 | MMP2 (0.54) | MMP2MMP9MMP8MMP1MMP3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0968182-B1 | HYDROXAMIC AND CARBOXYLIC ACID DERIVATIVES HAVING MMP AND TNF INHIBITORY ACTIVITY | DARWIN DISCOVERY LTD (GB) | 2004-05-06 | — | — | EP | claimed |