Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | STS | P08842 | 1/20 | 0.51 |
| ▸ | MMP9 | P14780 | 6/20 | 0.48 |
| ▸ | MMP8 | P22894 | 6/20 | 0.48 |
| ▸ | MMP2 | P08253 | 5/20 | 0.48 |
| ▸ | MMP1 | P03956 | 6/20 | 0.47 |
| ▸ | MMP3 | P08254 | 5/20 | 0.47 |
| ▸ | GPR119 | Q8TDV5 | 2/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.44 |
| ▸ | PKM | P14618 | 1/20 | 0.44 |
| ▸ | KEAP1 | Q14145 | 1/20 | 0.43 |
| ▸ | NFE2L2 | Q16236 | 1/20 | 0.43 |
| ▸ | JAK2 | O60674 | 1/20 | 0.42 |
| ▸ | JAK1 | P23458 | 1/20 | 0.42 |
| ▸ | MMP13 | P45452 | 3/20 | 0.42 |
| ▸ | PTPRB | P23467 | 1/20 | 0.42 |
| ▸ | PTPN11 | Q06124 | 1/20 | 0.42 |
| ▸ | TGFBR1 | P36897 | 1/20 | 0.41 |
| ▸ | SLC2A1 | P11166 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6578067 | 0.91 | STS (0.52) | STSMMP9MMP8MMP2MMP1 | |
| SCHEMBL6575904 | 0.85 | MMP1 (0.55) | MMP9MMP8MMP2MMP1MMP3 | |
| SCHEMBL6578655 | 0.82 | MMP2 (0.53) | MMP9MMP8MMP2MMP1MMP3 | |
| SCHEMBL6578119 | 0.79 | MMP2 (0.56) | MMP9MMP8MMP2MMP1MMP3 | |
| SCHEMBL13938143 | 0.78 | KDM4E (0.67) | STSGPR119KDM4EPKMKEAP1 | |
| SCHEMBL20137861 | 0.78 | STS (0.68) | STSGPR119KDM4EPKMKEAP1 | |
| Trifluoroacetic Acid SCHEMBL6578085 | 0.76 | MMP2 (0.51) | MMP9MMP8MMP2MMP1MMP3 | |
| SCHEMBL6578081 | 0.76 | MMP2 (0.48) | MMP9MMP8MMP2MMP1MMP3 | |
| SCHEMBL1979688 | 0.75 | STS (0.60) | STSGPR119KDM4EPKMKEAP1 | |
| SCHEMBL6580421 | 0.75 | KEAP1 (0.48) | STSGPR119KDM4EPKMKEAP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0968182-B1 | HYDROXAMIC AND CARBOXYLIC ACID DERIVATIVES HAVING MMP AND TNF INHIBITORY ACTIVITY | DARWIN DISCOVERY LTD (GB) | 2004-05-06 | — | — | EP | claimed |