Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | THRB | P10828 | 8/20 | 0.55 |
| ▸ | THRA | P10827 | 7/20 | 0.55 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.42 |
| ▸ | POLB | P06746 | 1/20 | 0.42 |
| ▸ | GAA | P10253 | 1/20 | 0.42 |
| ▸ | PTPN1 | P18031 | 2/20 | 0.41 |
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
| ▸ | GLRA1 | P23415 | 1/20 | 0.37 |
| ▸ | PSEN1 | P49768 | 1/20 | 0.37 |
| ▸ | PSEN2 | P49810 | 1/20 | 0.37 |
| ▸ | APH1B | Q8WW43 | 1/20 | 0.37 |
| ▸ | NCSTN | Q92542 | 1/20 | 0.37 |
| ▸ | APH1A | Q96BI3 | 1/20 | 0.37 |
| ▸ | PSENEN | Q9NZ42 | 1/20 | 0.37 |
| ▸ | AKR1C3 | P42330 | 1/20 | 0.36 |
| ▸ | AKR1C2 | P52895 | 1/20 | 0.36 |
| ▸ | AKR1C1 | Q04828 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6482781 | 0.85 | THRB (0.74) | THRBTHRAKDM4EALDH1A1POLB | |
| SCHEMBL6573415 | 0.83 | NQO1 (0.41) | THRBTHRAALDH1A1LMNA | |
| SCHEMBL6482824 | 0.72 | THRA (0.72) | THRBTHRAKDM4EALDH1A1POLB | |
| SCHEMBL3212510 | 0.71 | THRA (1.00) | THRBTHRAKDM4EALDH1A1POLB | |
| SCHEMBL29403217 | 0.71 | THRA (1.00) | THRBTHRAKDM4EALDH1A1POLB | |
| SCHEMBL6338264 | 0.66 | PTPN1 (0.68) | THRBTHRAPTPN1 | |
| SCHEMBL9474040 | 0.65 | KMT2A (0.55) | THRBTHRAALDH1A1POLBLMNA | |
| SCHEMBL6482244 | 0.65 | THRA (0.51) | THRBTHRAALDH1A1PTPN1LMNA | |
| SCHEMBL8498111 | 0.64 | FABP3 (0.52) | THRBTHRAALDH1A1GLRA1PSEN1 | |
| SCHEMBL6574630 | 0.64 | GABRA1 (0.51) | THRBALDH1A1POLBPTPN1LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1408958-A1 | BENZOFURANES AND THEIR USE IN THE TREATMENT OF ATRIAL FIBRILLATION | KARO BIO AB (SE) | 2004-04-21 | — | — | EP | disclosed |
| WO-2003009839-A1 | BENZOFURANES AND THEIR USE IN THE TREATMENT OF ATRIAL FIBRILLATION | KARO BIO AB (SE) | 2003-02-06 | — | — | WO | disclosed |