Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | THRA | P10827 | 1/20 | 0.51 |
| ▸ | THRB | P10828 | 1/20 | 0.51 |
| ▸ | NQO1 | P15559 | 5/20 | 0.44 |
| ▸ | CA2 | P00918 | 1/20 | 0.43 |
| ▸ | VKORC1 | Q9BQB6 | 4/20 | 0.39 |
| ▸ | CYP2C19 | P33261 | 3/20 | 0.39 |
| ▸ | EYA3 | Q99504 | 1/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | ABCB11 | O95342 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | TP53 | P04637 | 1/20 | 0.39 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.39 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.39 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.39 |
| ▸ | TSHR | P16473 | 1/20 | 0.39 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.39 |
| ▸ | PCSK7 | Q16549 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6573415 | 0.81 | NQO1 (0.41) | THRATHRBNQO1CA2VKORC1 | |
| SCHEMBL6482781 | 0.80 | THRB (0.74) | THRATHRBALDH1A1LMNAKMT2A | |
| SCHEMBL11342021 | 0.73 | DHFR (0.49) | CA2LMNACYP1A2CYP3A4TSHR | |
| SCHEMBL6490125 | 0.73 | EYA3 (0.69) | THRATHRBCYP2C19EYA3MEN1 | |
| Propofol SCHEMBL27586509 | 0.73 | HIF1A (0.53) | NQO1CA2VKORC1CYP2C19EYA3 | |
| SCHEMBL1121505 | 0.72 | GSR (0.53) | THRATHRBCA2LMNACYP1A2 | |
| SCHEMBL9442168 | 0.71 | GSR (0.52) | CA2LMNACYP1A2CYP3A4TSHR | |
| SCHEMBL9817081 | 0.70 | LMNA (0.45) | THRATHRBCA2LMNACYP1A2 | |
| SCHEMBL2467528 | 0.70 | GSR (0.63) | CA2LMNACYP1A2CYP3A4TSHR | |
| SCHEMBL17974165 | 0.69 | CA2 (0.53) | THRATHRBNQO1CA2CYP2C19 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20050065208-A1 | Benzofuranes and their use in the treatment of atrial fibrillation | KARO BIO AB (SE) | 2005-03-24 | — | — | US | claimed |
| US-20050065208-A1 | Benzofuranes and their use in the treatment of atrial fibrillation | KARO BIO AB (SE) | 2005-03-24 | — | — | US | disclosed |
| EP-1408958-A1 | BENZOFURANES AND THEIR USE IN THE TREATMENT OF ATRIAL FIBRILLATION | KARO BIO AB (SE) | 2004-04-21 | — | — | EP | disclosed |
| WO-2003009839-A1 | BENZOFURANES AND THEIR USE IN THE TREATMENT OF ATRIAL FIBRILLATION | KARO BIO AB (SE) | 2003-02-06 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050065208-A1 | Benzofuranes and their use in the treatment of atrial fibrillation | KCNH1, KCNJ2, KCNQ2 | THRA 1678/4885THRB 1466/4885NQO1 358/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.