Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BRAF | P15056 | 2/20 | 0.42 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.39 |
| ▸ | PLK4 | O00444 | 2/20 | 0.37 |
| ▸ | AURKA | O14965 | 2/20 | 0.37 |
| ▸ | DAPK3 | O43293 | 2/20 | 0.37 |
| ▸ | CHEK2 | O96017 | 2/20 | 0.37 |
| ▸ | CDK1 | P06493 | 2/20 | 0.37 |
| ▸ | PIM1 | P11309 | 2/20 | 0.37 |
| ▸ | PRKACA | P17612 | 2/20 | 0.37 |
| ▸ | CDK2 | P24941 | 2/20 | 0.37 |
| ▸ | MAPK9 | P45984 | 2/20 | 0.37 |
| ▸ | CSNK1D | P48730 | 2/20 | 0.37 |
| ▸ | GSK3A | P49840 | 2/20 | 0.37 |
| ▸ | GSK3B | P49841 | 2/20 | 0.37 |
| ▸ | RPS6KA3 | P51812 | 2/20 | 0.37 |
| ▸ | CSNK2A1 | P68400 | 2/20 | 0.37 |
| ▸ | DYRK1A | Q13627 | 2/20 | 0.37 |
| ▸ | AURKB | Q96GD4 | 2/20 | 0.37 |
| ▸ | PLK3 | Q9H4B4 | 2/20 | 0.37 |
| ▸ | SGK2 | Q9HBY8 | 2/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5620698 | 0.80 | ALDH1A1 (0.46) | BRAFALOX5PLK4AURKADAPK3 | |
| SCHEMBL9868855 | 0.80 | ALOX5 (0.45) | BRAFALOX5PLK4AURKADAPK3 | |
| SCHEMBL6437003 | 0.78 | GPR3 (0.46) | PTPN1MAPK1NPC1RAB9AALDH1A1 | |
| SCHEMBL659162 | 0.74 | IMPDH2 (0.40) | AURKADAPK3PIM1PRKACAGSK3A | |
| SCHEMBL2150616 | 0.74 | PTPN1 (0.37) | ALOX5PTPN1MAPK1LIMK1NPC1 | |
| SCHEMBL29765328 | 0.72 | LIMK1 (0.43) | ALOX5PTPN1MAPK1LIMK1ROCK1 | |
| SCHEMBL28415064 | 0.72 | LIMK1 (0.43) | ALOX5PTPN1MAPK1LIMK1ROCK1 | |
| SCHEMBL660127 | 0.72 | KDM4E (0.40) | AURKADAPK3PIM1PRKACACDK2 | |
| SCHEMBL9869471 | 0.71 | BRAF (0.37) | BRAFALOX5PLK4AURKADAPK3 | |
| SCHEMBL9868772 | 0.71 | ALOX5 (0.46) | BRAFALOX5PLK4AURKADAPK3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8378104-B2 | 7-aminofuropyridine derivatives | OSI Pharmaceuticals, LLC (US) | 2013-02-19 | — | — | US | disclosed |
| US-20120046267-A1 | 7-AMINOFUROPYRIDINE DERIVATIVES | OSI PHARMACEUTICALS, INC. | 2012-02-23 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120046267-A1 | 7-AMINOFUROPYRIDINE DERIVATIVES | MAP3K5, STK17A, MAPKAPK5 | BRAF 277/4885ALOX5 2680/4885PLK4 653/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.