Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BDKRB2 | P30411 | 2/20 | 0.37 |
| ▸ | KLKB1 | P03952 | 1/20 | 0.37 |
| ▸ | CA1 | P00915 | 1/20 | 0.36 |
| ▸ | CA2 | P00918 | 1/20 | 0.36 |
| ▸ | KCNH2 | Q12809 | 3/20 | 0.35 |
| ▸ | TP53 | P04637 | 1/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.35 |
| ▸ | NPC1 | O15118 | 2/20 | 0.35 |
| ▸ | RAB9A | P51151 | 2/20 | 0.35 |
| ▸ | MEN1 | O00255 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.35 |
| ▸ | MAPT | P10636 | 2/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.35 |
| ▸ | GAA | P10253 | 1/20 | 0.35 |
| ▸ | HPGD | P15428 | 1/20 | 0.35 |
| ▸ | TSHR | P16473 | 1/20 | 0.35 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.35 |
| ▸ | LMNA | P02545 | 1/20 | 0.34 |
| ▸ | BLM | P54132 | 1/20 | 0.34 |
| ▸ | THRB | P10828 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7906001 | 0.80 | BDKRB2 (0.54) | BDKRB2MAPTALDH1A1HPGDLMNA | |
| SCHEMBL6578780 | 0.77 | NCF1 (0.40) | KLKB1KDM4ENPC1RAB9AMAPT | |
| SCHEMBL6576127 | 0.75 | S1PR4 (0.42) | KLKB1TP53NPC1RAB9AKMT2A | |
| SCHEMBL6936592 | 0.69 | KDM4E (0.42) | KDM4ENPC1RAB9AMAPTALDH1A1 | |
| SCHEMBL8097174 | 0.69 | BDKRB2 (0.40) | BDKRB2KLKB1KDM4ERAB9AALDH1A1 | |
| SCHEMBL6581385 | 0.68 | TP53 (0.42) | TP53NPC1MEN1KMT2AMAPT | |
| SCHEMBL6935565 | 0.67 | BDKRB2 (0.46) | BDKRB2 | |
| SCHEMBL6580627 | 0.66 | NCF1 (0.41) | KDM4EMAPTALDH1A1GAATSHR | |
| SCHEMBL6576073 | 0.66 | KDM4E (0.38) | KDM4ENPC1RAB9AMEN1KMT2A | |
| SCHEMBL8098950 | 0.66 | S1PR4 (0.37) | BDKRB2KLKB1KDM4EMAPTALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0867432-B1 | Fused N-heterocyclic compounds substituted with benzyloxy, process for their preparation and their use as bradykinin receptor antagonists | AVENTIS PHARMA GMBH (DE) | 2004-06-09 | — | — | EP | disclosed |
| EP-0867432-A2 | Fused N-heterocyclic compounds substituted with benzyloxy, process for their preparation and their use as bradykinin receptor antagonists | HOECHST AKTIENGESELLSCHAFT (DE) | 1998-09-30 | — | — | EP | disclosed |