Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.44 |
| ▸ | CA12 | O43570 | 2/20 | 0.42 |
| ▸ | CA1 | P00915 | 2/20 | 0.42 |
| ▸ | CA2 | P00918 | 2/20 | 0.42 |
| ▸ | CA9 | Q16790 | 2/20 | 0.42 |
| ▸ | CA7 | P43166 | 1/20 | 0.42 |
| ▸ | CA14 | Q9ULX7 | 1/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.41 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.41 |
| ▸ | MEN1 | O00255 | 2/20 | 0.41 |
| ▸ | CAPN1 | P07384 | 1/20 | 0.41 |
| ▸ | HTR2A | P28223 | 1/20 | 0.41 |
| ▸ | MMP1 | P03956 | 2/20 | 0.41 |
| ▸ | MMP2 | P08253 | 2/20 | 0.41 |
| ▸ | MMP3 | P08254 | 2/20 | 0.41 |
| ▸ | MMP9 | P14780 | 2/20 | 0.41 |
| ▸ | MMP8 | P22894 | 2/20 | 0.41 |
| ▸ | ADRB3 | P13945 | 1/20 | 0.40 |
| ▸ | EPHX1 | P07099 | 1/20 | 0.40 |
| ▸ | ACHE | P22303 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydroxyamine SCHEMBL6580410 | 0.89 | MMP1 (0.50) | SIGMAR1CA12CA1CA2CA9 | |
| SCHEMBL6581071 | 0.89 | MMP1 (0.52) | SIGMAR1CA12CA1CA2CA9 | |
| SCHEMBL6575904 | 0.85 | MMP1 (0.55) | SIGMAR1CA12CA1CA2CA9 | |
| SCHEMBL6578067 | 0.75 | STS (0.52) | MMP1MMP2MMP3MMP9MMP8 | |
| SCHEMBL6580383 | 0.74 | HTR2A (0.50) | SIGMAR1KMT2AKCNH2MEN1HTR2A | |
| SCHEMBL7079165 | 0.73 | MMP2 (0.54) | MMP1MMP2MMP3MMP9MMP8 | |
| SCHEMBL6578667 | 0.72 | STS (0.51) | MMP1MMP2MMP3MMP9MMP8 | |
| SCHEMBL6578105 | 0.71 | SIGMAR1 (0.49) | SIGMAR1KMT2AKCNH2MEN1MMP1 | |
| SCHEMBL6578655 | 0.71 | MMP2 (0.53) | SIGMAR1KCNH2HTR2AMMP1MMP2 | |
| SCHEMBL27740557 | 0.70 | GRIK1 (0.55) | MMP1MMP2MMP3MMP9MMP8 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0968182-B1 | HYDROXAMIC AND CARBOXYLIC ACID DERIVATIVES HAVING MMP AND TNF INHIBITORY ACTIVITY | DARWIN DISCOVERY LTD (GB) | 2004-05-06 | — | — | EP | claimed |