Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DRD2 | P14416 | 11/20 | 0.43 |
| ▸ | DRD3 | P35462 | 8/20 | 0.43 |
| ▸ | HTR1D | P28221 | 2/20 | 0.43 |
| ▸ | DRD4 | P21917 | 6/20 | 0.42 |
| ▸ | HTR5A | P47898 | 1/20 | 0.42 |
| ▸ | DRD1 | P21728 | 4/20 | 0.41 |
| ▸ | DRD5 | P21918 | 4/20 | 0.41 |
| ▸ | MTNR1A | P48039 | 1/20 | 0.39 |
| ▸ | MTNR1B | P49286 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6583279 | 0.81 | MTNR1A (0.42) | DRD2DRD3HTR1DMTNR1AMTNR1B | |
| SCHEMBL9242197 | 0.80 | MTNR1B (0.43) | MTNR1AMTNR1B | |
| SCHEMBL19436094 | 0.77 | DRD2 (0.42) | DRD2DRD3HTR1DDRD4HTR5A | |
| SCHEMBL1285355 | 0.76 | DRD2 (0.46) | DRD2DRD3HTR1DDRD4HTR5A | |
| SCHEMBL30042062 | 0.75 | DRD2 (0.55) | DRD2DRD3HTR1DDRD4HTR5A | |
| SCHEMBL6582526 | 0.75 | PTGS2 (0.40) | DRD2DRD3HTR1DDRD4HTR5A | |
| SCHEMBL22488448 | 0.73 | DRD2 (0.36) | DRD2DRD3HTR1DDRD4HTR5A | |
| SCHEMBL360947 | 0.73 | MTNR1B (0.50) | MTNR1AMTNR1B | |
| SCHEMBL8823791 | 0.73 | DRD2 (0.48) | DRD2DRD3HTR1DDRD4HTR5A | |
| SCHEMBL1820878 | 0.73 | DRD2 (0.53) | DRD2DRD3HTR1DDRD4HTR5A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1189900-B1 | HETEROCYCLIC AMINOPYRROLIDINE DERIVATIVES AS MELATONERGIC AGENTS | BRISTOL MYERS SQUIBB CO (US) | 2004-01-14 | — | — | EP | disclosed |
| EP-1082115-A4 | HETEROCYCLIC CIS CYCLOPROPANE DERIVATIVES AS MELATONERGIC AGENTS | BRISTOL MYERS SQUIBB CO (US) | 2002-10-24 | — | — | EP | disclosed |
| EP-1189900-A4 | HETEROCYCLIC AMINOPYRROLIDINE DERIVATIVES AS MELATONERGIC AGENTS | BRISTOL MYERS SQUIBB CO (US) | 2002-07-31 | — | — | EP | disclosed |
| EP-1189900-A1 | HETEROCYCLIC AMINOPYRROLIDINE DERIVATIVES AS MELATONERGIC AGENTS | BRISTOL-MYERS SQUIBB COMPANY (US) | 2002-03-27 | — | — | EP | disclosed |
| US-6214869-B1 | SLEEP DISORDERS | BRISTOL-MYERS SQUIBB | 2001-04-10 | — | — | US | disclosed |
| US-6211225-B1 | SLEEP DISORDERS AND CIRCADIAN RHYTHM DISORDERS | BRISTOL-MEYERS SQUIBB | 2001-04-03 | — | — | US | disclosed |
| EP-1082115-A1 | HETEROCYCLIC CIS CYCLOPROPANE DERIVATIVES AS MELATONERGIC AGENTS | BRISTOL-MYERS SQUIBB COMPANY (US) | 2001-03-14 | — | — | EP | disclosed |
| WO-2001002392-A1 | HETEROCYCLIC AMINOPYRROLIDINE DERIVATIVES AS MELATONERGIC AGENTS | BRISTOL-MYERS SQUIBB COMPANY (US) | 2001-01-11 | — | — | WO | disclosed |
| WO-1999062515-A1 | HETEROCYCLIC CIS CYCLOPROPANE DERIVATIVES AS MELATONERGIC AGENTS | BRISTOL-MYERS SQUIBB COMPANY (US) | 1999-12-09 | — | — | WO | disclosed |