Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MTNR1A | P48039 | 5/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.40 |
| ▸ | PTGS2 | P35354 | 3/20 | 0.40 |
| ▸ | CTNNB1 | P35222 | 1/20 | 0.39 |
| ▸ | WNT3A | P56704 | 1/20 | 0.39 |
| ▸ | MTNR1B | P49286 | 1/20 | 0.38 |
| ▸ | ACLY | P53396 | 1/20 | 0.37 |
| ▸ | DRD2 | P14416 | 3/20 | 0.36 |
| ▸ | HTR1D | P28221 | 2/20 | 0.36 |
| ▸ | DRD3 | P35462 | 2/20 | 0.36 |
| ▸ | PTGS1 | P23219 | 3/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6582526 | 0.88 | PTGS2 (0.40) | PTGS2DRD2HTR1DDRD3PTGS1 | |
| SCHEMBL6580676 | 0.81 | DRD2 (0.43) | MTNR1AMTNR1BDRD2HTR1DDRD3 | |
| SCHEMBL30330332 | 0.78 | DRD2 (0.35) | DRD2HTR1DDRD3 | |
| SCHEMBL15997038 | 0.77 | CETP (0.40) | KDM4EPTGS2DRD2DRD3PTGS1 | |
| SCHEMBL22488448 | 0.75 | DRD2 (0.36) | DRD2HTR1DDRD3 | |
| SCHEMBL6983435 | 0.74 | CA2 (0.39) | DRD2HTR1DDRD3 | |
| SCHEMBL6983439 | 0.74 | CA2 (0.39) | DRD2HTR1DDRD3 | |
| SCHEMBL17833950 | 0.74 | DRD2 (0.41) | KDM4EDRD2HTR1DDRD3 | |
| SCHEMBL6338640 | 0.73 | DRD2 (0.34) | DRD2HTR1DDRD3 | |
| SCHEMBL1201009 | 0.72 | ALDH1A1 (0.62) | DRD2DRD3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1189900-B1 | HETEROCYCLIC AMINOPYRROLIDINE DERIVATIVES AS MELATONERGIC AGENTS | BRISTOL MYERS SQUIBB CO (US) | 2004-01-14 | — | — | EP | disclosed |
| EP-1189900-A4 | HETEROCYCLIC AMINOPYRROLIDINE DERIVATIVES AS MELATONERGIC AGENTS | BRISTOL MYERS SQUIBB CO (US) | 2002-07-31 | — | — | EP | disclosed |
| EP-1189900-A1 | HETEROCYCLIC AMINOPYRROLIDINE DERIVATIVES AS MELATONERGIC AGENTS | BRISTOL-MYERS SQUIBB COMPANY (US) | 2002-03-27 | — | — | EP | disclosed |
| US-6211225-B1 | SLEEP DISORDERS AND CIRCADIAN RHYTHM DISORDERS | BRISTOL-MEYERS SQUIBB | 2001-04-03 | — | — | US | disclosed |
| WO-2001002392-A1 | HETEROCYCLIC AMINOPYRROLIDINE DERIVATIVES AS MELATONERGIC AGENTS | BRISTOL-MYERS SQUIBB COMPANY (US) | 2001-01-11 | — | — | WO | disclosed |