SCHEMBL6580973

SCHEMBL6580973

NNC(=O)c1ccc(OCF)c(F)c1

nearest known ligand 0.45

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
KCNQ3 O43525 2/20 0.45
KCNQ2 O43526 2/20 0.45
TAS1R3 Q7RTX0 1/20 0.45
TAS1R1 Q7RTX1 1/20 0.45
ALDH1A1 P00352 6/20 0.43
MAPT P10636 5/20 0.43
L3MBTL1 Q9Y468 3/20 0.43
LMNA P02545 3/20 0.42
HTT P42858 2/20 0.42
HDAC1 Q13547 1/20 0.42
HDAC6 Q9UBN7 1/20 0.42
MAPK1 P28482 1/20 0.42
RAB9A P51151 1/20 0.42
CYP3A4 P08684 2/20 0.42
MEN1 O00255 1/20 0.42
CYP1A2 P05177 1/20 0.42
CYP2D6 P10635 1/20 0.42
CYP2C9 P11712 1/20 0.42
CYP2C19 P33261 1/20 0.42
KMT2A Q03164 1/20 0.42

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL6578700 0.86 KCNQ3 (0.60) KCNQ3KCNQ2TAS1R3TAS1R1ALDH1A1
SCHEMBL30622701 0.82 HTT (0.65) KCNQ3KCNQ2TAS1R3TAS1R1ALDH1A1
SCHEMBL6582492 0.82 HTT (0.65) KCNQ3KCNQ2TAS1R3TAS1R1ALDH1A1
SCHEMBL6581244 0.81 LMNA (0.50) KCNQ3KCNQ2TAS1R3TAS1R1ALDH1A1
Hydrochloric Acid SCHEMBL6510141 0.81 HTT (0.63) KCNQ3KCNQ2TAS1R3TAS1R1ALDH1A1
SCHEMBL6581621 0.79 TAS1R3 (0.47) KCNQ3KCNQ2TAS1R3TAS1R1ALDH1A1
SCHEMBL5637289 0.79 THRA (0.58) KCNQ3KCNQ2TAS1R3TAS1R1ALDH1A1
SCHEMBL21974593 0.78 KCNQ3 (0.58) KCNQ3KCNQ2TAS1R3TAS1R1ALDH1A1
SCHEMBL1128282 0.77 CES2 (0.59) KCNQ3KCNQ2TAS1R3TAS1R1ALDH1A1
SCHEMBL29717191 0.77 CES2 (0.59) KCNQ3KCNQ2TAS1R3TAS1R1ALDH1A1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1070708-B1 Triazole derivatives HOFFMANN LA ROCHE (CH) 2004-01-14 EP disclosed
US-6265426-B1 CENTRAL NERVOUS SYSTEM DISORDERS HOFFMANN-LA ROCHE INC. 2001-07-24 US disclosed
EP-1070708-A1 Triazole and imidazole derivatives F. HOFFMANN-LA ROCHE AG (CH) 2001-01-24 EP disclosed