Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PPARG | P37231 | 7/20 | 0.46 |
| ▸ | PPARA | Q07869 | 6/20 | 0.43 |
| ▸ | LPAR1 | Q92633 | 2/20 | 0.39 |
| ▸ | P4HTM | Q9NXG6 | 1/20 | 0.38 |
| ▸ | S1PR1 | P21453 | 5/20 | 0.38 |
| ▸ | PTPN1 | P18031 | 2/20 | 0.37 |
| ▸ | PTGDR2 | Q9Y5Y4 | 1/20 | 0.37 |
| ▸ | S1PR3 | Q99500 | 3/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.36 |
| ▸ | EPHX1 | P07099 | 1/20 | 0.36 |
| ▸ | LPAR3 | Q9UBY5 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6581 | 0.91 | CHRM1 (0.40) | PPARGPPARALPAR1S1PR1PTPN1 | |
| SCHEMBL7249 | 0.86 | PPARG (0.51) | PPARGPPARALPAR1P4HTMPTPN1 | |
| SCHEMBL6889 | 0.85 | FFAR1 (0.46) | PPARGPPARALPAR1S1PR1S1PR3 | |
| SCHEMBL7481 | 0.83 | LPAR1 (0.55) | LPAR1S1PR1PTGDR2S1PR3ALDH1A1 | |
| SCHEMBL7242 | 0.82 | LIPG (0.44) | PPARGPPARALPAR1S1PR1S1PR3 | |
| SCHEMBL6190 | 0.82 | PPARG (0.46) | PPARGPPARALPAR1P4HTMPTPN1 | |
| SCHEMBL6024 | 0.79 | LPAR1 (0.46) | PPARGPPARALPAR1S1PR1S1PR3 | |
| SCHEMBL6801 | 0.79 | SMN1; SMN2 (0.46) | LPAR1S1PR1S1PR3ALDH1A1L3MBTL1 | |
| SCHEMBL7190 | 0.78 | LPAR1 (0.40) | PPARGPPARALPAR1S1PR1S1PR3 | |
| SCHEMBL6779 | 0.78 | LPAR1 (0.42) | PPARGPPARALPAR1S1PR1PTPN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2483252-A2 | COMPOUNDS AS LYSOPHOSPHATIDIC ACID RECEPTOR ANTAGONISTS | Amira Pharmaceuticals, Inc. (US) | 2012-08-08 | — | — | EP | claimed |
| WO-2011041694-A2 | COMPOUNDS AS LYSOPHOSPHATIDIC ACID RECEPTOR ANTAGONISTS | AMIRA PHARMACEUTICALS, INC. (US) | 2011-04-07 | — | — | WO | claimed |
| EP-2483252-A2 | COMPOUNDS AS LYSOPHOSPHATIDIC ACID RECEPTOR ANTAGONISTS | Amira Pharmaceuticals, Inc. (US) | 2012-08-08 | — | — | EP | disclosed |
| WO-2011041694-A2 | COMPOUNDS AS LYSOPHOSPHATIDIC ACID RECEPTOR ANTAGONISTS | AMIRA PHARMACEUTICALS, INC. (US) | 2011-04-07 | — | — | WO | disclosed |