Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR7 | P34969 | 1/20 | 0.46 |
| ▸ | CSF1R | P07333 | 1/20 | 0.45 |
| ▸ | AVPR1B | P47901 | 1/20 | 0.45 |
| ▸ | S1PR1 | P21453 | 1/20 | 0.43 |
| ▸ | HSD17B2 | P37059 | 1/20 | 0.42 |
| ▸ | PSEN1 | P49768 | 2/20 | 0.42 |
| ▸ | PSEN2 | P49810 | 2/20 | 0.42 |
| ▸ | APH1B | Q8WW43 | 2/20 | 0.42 |
| ▸ | NCSTN | Q92542 | 2/20 | 0.42 |
| ▸ | APH1A | Q96BI3 | 2/20 | 0.42 |
| ▸ | PSENEN | Q9NZ42 | 2/20 | 0.42 |
| ▸ | TDP2 | O95551 | 1/20 | 0.40 |
| ▸ | TLR8 | Q9NR97 | 2/20 | 0.40 |
| ▸ | TLR7 | Q9NYK1 | 2/20 | 0.40 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.40 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.40 |
| ▸ | TLR9 | Q9NR96 | 1/20 | 0.40 |
| ▸ | NPC1 | O15118 | 2/20 | 0.40 |
| ▸ | RAB9A | P51151 | 2/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6584053 | 0.84 | ACP1 (0.46) | HTR7AVPR1BHSD17B2ADORA2AADORA1 | |
| Hydrochloric Acid SCHEMBL6580533 | 0.83 | ACP1 (0.45) | HTR7AVPR1BHSD17B2ADORA2AADORA1 | |
| SCHEMBL6581290 | 0.81 | NR1H2 (0.50) | HTR7S1PR1HSD17B2TDP2ADORA2A | |
| Hydrochloric Acid SCHEMBL6580743 | 0.80 | NR1H2 (0.49) | HTR7S1PR1HSD17B2TDP2ADORA2A | |
| SCHEMBL6580847 | 0.79 | TDP2 (0.44) | HSD17B2PSEN1PSEN2APH1BNCSTN | |
| SCHEMBL6580791 | 0.78 | TNK2 (0.43) | HTR7AVPR1BS1PR1HSD17B2ADORA2A | |
| SCHEMBL6580942 | 0.78 | HTR7 (0.46) | HTR7CSF1RS1PR1PSEN1PSEN2 | |
| Hydrochloric Acid SCHEMBL6581027 | 0.77 | HTR7 (0.46) | HTR7CSF1RS1PR1PSEN1PSEN2 | |
| Hydrochloric Acid SCHEMBL6583998 | 0.77 | TNK2 (0.42) | HTR7AVPR1BS1PR1HSD17B2ADORA2A | |
| Hydrochloric Acid SCHEMBL6580650 | 0.72 | NR1H3 (0.52) | HTR7AVPR1BS1PR1ALDH1A1LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1070708-B1 | Triazole derivatives | HOFFMANN LA ROCHE (CH) | 2004-01-14 | — | — | EP | claimed |
| US-6265426-B1 | CENTRAL NERVOUS SYSTEM DISORDERS | HOFFMANN-LA ROCHE INC. | 2001-07-24 | — | — | US | claimed |
| EP-1070708-A1 | Triazole and imidazole derivatives | F. HOFFMANN-LA ROCHE AG (CH) | 2001-01-24 | — | — | EP | claimed |
| EP-1070708-B1 | Triazole derivatives | HOFFMANN LA ROCHE (CH) | 2004-01-14 | — | — | EP | disclosed |
| US-6265426-B1 | CENTRAL NERVOUS SYSTEM DISORDERS | HOFFMANN-LA ROCHE INC. | 2001-07-24 | — | — | US | disclosed |
| EP-1070708-A1 | Triazole and imidazole derivatives | F. HOFFMANN-LA ROCHE AG (CH) | 2001-01-24 | — | — | EP | disclosed |