Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TDP2 | O95551 | 2/20 | 0.44 |
| ▸ | HSD17B2 | P37059 | 1/20 | 0.44 |
| ▸ | PSEN1 | P49768 | 3/20 | 0.43 |
| ▸ | PSEN2 | P49810 | 3/20 | 0.43 |
| ▸ | APH1B | Q8WW43 | 3/20 | 0.43 |
| ▸ | NCSTN | Q92542 | 3/20 | 0.43 |
| ▸ | APH1A | Q96BI3 | 3/20 | 0.43 |
| ▸ | PSENEN | Q9NZ42 | 3/20 | 0.43 |
| ▸ | NPC1 | O15118 | 5/20 | 0.41 |
| ▸ | RAB9A | P51151 | 5/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.41 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.41 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.41 |
| ▸ | RELA | Q04206 | 1/20 | 0.41 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.41 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.40 |
| ▸ | PDGFRA | P16234 | 1/20 | 0.40 |
| ▸ | LMNA | P02545 | 2/20 | 0.40 |
| ▸ | MAPT | P10636 | 2/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6578166 | 0.83 | HSD17B2 (0.51) | TDP2HSD17B2PSEN1PSEN2APH1B | |
| SCHEMBL6580839 | 0.83 | KDM4C (0.49) | TDP2HSD17B2PSEN1PSEN2APH1B | |
| SCHEMBL6581144 | 0.80 | NR1H2 (0.53) | TDP2HSD17B2NPC1RAB9AALDH1A1 | |
| SCHEMBL6581048 | 0.79 | HTR7 (0.46) | TDP2HSD17B2PSEN1PSEN2APH1B | |
| SCHEMBL6581289 | 0.77 | DRD1 (0.46) | TDP2HSD17B2PSEN1PSEN2APH1B | |
| Pyrrolidine SCHEMBL6582654 | 0.76 | KDM4C (0.43) | HSD17B2PSEN1PSEN2APH1BNCSTN | |
| SCHEMBL30514362 | 0.71 | ALDH1A1 (0.65) | ALDH1A1SMN1; SMN2LMNAMAPTERN1 | |
| SCHEMBL4937479 | 0.71 | ALDH1A1 (0.65) | ALDH1A1SMN1; SMN2LMNAMAPTERN1 | |
| SCHEMBL6584148 | 0.71 | NR1H3 (0.48) | NPC1RAB9AALDH1A1SMN1; SMN2NR1H2 | |
| SCHEMBL6581365 | 0.71 | NR1H3 (0.43) | NPC1RAB9ANR1H2NR1H3TSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1070708-B1 | Triazole derivatives | HOFFMANN LA ROCHE (CH) | 2004-01-14 | — | — | EP | disclosed |
| US-6265426-B1 | CENTRAL NERVOUS SYSTEM DISORDERS | HOFFMANN-LA ROCHE INC. | 2001-07-24 | — | — | US | disclosed |
| EP-1070708-A1 | Triazole and imidazole derivatives | F. HOFFMANN-LA ROCHE AG (CH) | 2001-01-24 | — | — | EP | disclosed |