Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | S1PR4 | O95977 | 5/20 | 0.37 |
| ▸ | PPARG | P37231 | 1/20 | 0.37 |
| ▸ | NCF1 | P14598 | 4/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.35 |
| ▸ | LMNA | P02545 | 1/20 | 0.35 |
| ▸ | POLB | P06746 | 1/20 | 0.35 |
| ▸ | CASP6 | P55212 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.35 |
| ▸ | CASP1 | P29466 | 1/20 | 0.35 |
| ▸ | CASP7 | P55210 | 1/20 | 0.35 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.35 |
| ▸ | BDKRB2 | P30411 | 2/20 | 0.35 |
| ▸ | TEC | P42680 | 1/20 | 0.35 |
| ▸ | KLKB1 | P03952 | 1/20 | 0.35 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.34 |
| ▸ | MAPT | P10636 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8097174 | 0.83 | BDKRB2 (0.40) | S1PR4PPARGNCF1KDM4EALDH1A1 | |
| SCHEMBL6936592 | 0.83 | KDM4E (0.42) | NCF1KDM4ELMNAPOLBCASP6 | |
| SCHEMBL8106164 | 0.81 | HPGD (0.44) | LMNAALDH1A1KLKB1CYP1A2 | |
| SCHEMBL8098948 | 0.77 | BDKRB2 (0.61) | KDM4ELMNABDKRB2 | |
| SCHEMBL8169656 | 0.77 | BDKRB2 (0.41) | S1PR4BDKRB2 | |
| SCHEMBL8099739 | 0.77 | BDKRB2 (0.42) | PPARGKDM4ELMNAPOLBBDKRB2 | |
| SCHEMBL6581385 | 0.76 | TP53 (0.42) | S1PR4LMNAALDH1A1CYP1A2MAPT | |
| SCHEMBL6935565 | 0.76 | BDKRB2 (0.46) | BDKRB2 | |
| SCHEMBL6578833 | 0.76 | NCF1 (0.40) | PPARGNCF1KDM4ELMNAPOLB | |
| SCHEMBL6578780 | 0.76 | NCF1 (0.40) | NCF1KDM4ELMNAPOLBCASP6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0795547-B1 | (Aminoalkyl- and acylaminoalkyl-oxy)benzyloxyquinolines, process for their preparation and use as Bradykinin receptor antagonists | HOECHST AG (DE) | 2000-05-10 | — | — | EP | claimed |
| EP-0795547-B1 | (Aminoalkyl- and acylaminoalkyl-oxy)benzyloxyquinolines, process for their preparation and use as Bradykinin receptor antagonists | HOECHST AG (DE) | 2000-05-10 | — | — | EP | disclosed |
| EP-0795547-A1 | (Aminoalkyl- and acylaminoalkyl-oxy)benzyloxyquinolines, process for their preparation and use as Bradykinin receptor antagonists | HOECHST AKTIENGESELLSCHAFT (DE) | 1997-09-17 | — | — | EP | disclosed |