Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP19A1 | P11511 | 2/20 | 0.59 |
| ▸ | MAPT | P10636 | 2/20 | 0.51 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.51 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.51 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.51 |
| ▸ | RAB9A | P51151 | 1/20 | 0.51 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.51 |
| ▸ | RELA | Q04206 | 1/20 | 0.51 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.49 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.48 |
| ▸ | LMNA | P02545 | 1/20 | 0.48 |
| ▸ | HSD17B1 | P14061 | 2/20 | 0.46 |
| ▸ | HSD17B2 | P37059 | 2/20 | 0.46 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.46 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.46 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.46 |
| ▸ | CLK4 | Q9HAZ1 | 1/20 | 0.46 |
| ▸ | TRPM8 | Q7Z2W7 | 1/20 | 0.44 |
| ▸ | USP2 | O75604 | 2/20 | 0.44 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20588052 | 0.81 | CYP19A1 (0.59) | CYP19A1MAPTTDP1SMN1; SMN2NFKB1 | |
| SCHEMBL8715461 | 0.81 | CYP19A1 (0.59) | CYP19A1MAPTTDP1SMN1; SMN2NFKB1 | |
| SCHEMBL29673242 | 0.81 | CYP19A1 (0.59) | CYP19A1MAPTTDP1SMN1; SMN2NFKB1 | |
| SCHEMBL28406603 | 0.80 | CYP19A1 (0.73) | CYP19A1MAPTTDP1SMN1; SMN2NFKB1 | |
| SCHEMBL30287350 | 0.80 | CYP19A1 (0.73) | CYP19A1MAPTTDP1SMN1; SMN2NFKB1 | |
| SCHEMBL6581811 | 0.74 | ADORA3 (0.59) | MAPTSMN1; SMN2RAB9AALDH1A1KDM4E | |
| SCHEMBL8838311 | 0.74 | CYP19A1 (0.48) | CYP19A1MAPTTDP1SMN1; SMN2NFKB1 | |
| SCHEMBL6579923 | 0.74 | CYP19A1 (0.51) | CYP19A1MAPTTDP1SMN1; SMN2NFKB1 | |
| SCHEMBL1180747 | 0.73 | RAB9A (0.59) | MAPTTDP1SMN1; SMN2NFKB1RAB9A | |
| SCHEMBL1180755 | 0.73 | HSD17B1 (0.74) | CYP19A1MAPTSMN1; SMN2RAB9AHSD17B1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0737680-B1 | (Phenylalkylaminoalkyloxyl)-hetero-aryl compounds, processes and intermediates for their preparation and medicaments containing these compounds | SOLVAY PHARM GMBH (DE) | 2004-03-03 | — | — | EP | disclosed |
| EP-0737680-A1 | (Phenylalkylaminoalkyloxyl)-hetero-aryl compounds, processes and intermediates for their preparation and medicaments containing these compounds | Kali-Chemie Pharma GmbH (DE) | 1996-10-16 | — | — | EP | disclosed |