Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ENPP2 | Q13822 | 11/20 | 0.80 |
| ▸ | MAPT | P10636 | 5/20 | 0.66 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.64 |
| ▸ | HTT | P42858 | 1/20 | 0.64 |
| ▸ | TP53 | P04637 | 1/20 | 0.64 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.62 |
| ▸ | LDHA | P00338 | 1/20 | 0.60 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.59 |
| ▸ | PKM | P14618 | 1/20 | 0.59 |
| ▸ | LMNA | P02545 | 1/20 | 0.57 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.56 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL6581412 | 0.83 | MAPK1 (0.59) | ENPP2MAPTALDH1A1HTTKMT2A | |
| SCHEMBL19145333 | 0.80 | KMT2A (0.74) | ENPP2MAPTALDH1A1HTTKMT2A | |
| SCHEMBL7253850 | 0.78 | MAPT (0.54) | ENPP2MAPTALDH1A1HTTTP53 | |
| SCHEMBL28575185 | 0.78 | ALDH1A1 (0.68) | ENPP2ALDH1A1HTTKMT2AKDM4E | |
| SCHEMBL13153237 | 0.78 | MAPT (0.68) | ENPP2MAPTALDH1A1HTTTP53 | |
| SCHEMBL13531595 | 0.77 | KMT2A (0.70) | ENPP2MAPTALDH1A1KMT2AKDM4E | |
| SCHEMBL1387486 | 0.76 | MAPT (0.74) | MAPTALDH1A1HTTTP53KMT2A | |
| SCHEMBL13181103 | 0.74 | MAPT (0.70) | MAPTALDH1A1HTTTP53KMT2A | |
| SCHEMBL8932385 | 0.73 | MAPT (0.69) | ENPP2MAPTALDH1A1HTTTP53 | |
| SCHEMBL942925 | 0.73 | MAPT (0.69) | MAPTALDH1A1HTTTP53KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1060175-B1 | TRYPTASE INHIBITORS | MAX PLANCK GESELLSCHAFT (DE) | 2004-11-17 | — | — | EP | disclosed |
| US-6613769-B1 | Incubating samples with enzyme inhibitors, then determining complexes formed; medical diagnosis; therapy for allergies and inflammation | Max-Planck-Gesellschaft zur Föderung der Wissenschaften. e.V. (DE) | 2003-09-02 | — | — | US | disclosed |
| US-6489327-B1 | TREATING A DISEASE SUSCEPTIBLE TO TRYPTASE INHIBITION SUCH AS ASTHMA, INFLAMMATORY BOWEL DISEASE, PSORIASIS OR RHINITIS | MAX-PLANCK-GESELLSCHAFT ZUR FORDRUNGDER WISENSCHAFTEN, E.V. (DE) | 2002-12-03 | — | — | US | disclosed |
| EP-1060171-A2 | TRYPTASE INHIBITORS | Max-Planck-Gesellschaft zur Förderung der Wissenschaften e.V. (DE) | 2000-12-20 | — | — | EP | disclosed |
| EP-1060175-A2 | TRYPTASE INHIBITORS | Max-Planck-Gesellschaft zur Förderung der Wissenschaften e.V. (DE) | 2000-12-20 | — | — | EP | disclosed |
| WO-1999040083-A2 | BIFUNCTIONAL TRYPTASE INHIBITORS | MAX-PLANCK-Gesellschaft zur Förderung der Wissenschaften e.V. (DE) | 1999-08-12 | — | — | WO | disclosed |
| WO-1999040073-A2 | TRYPTASE INHIBITORS | MAX-PLANCK-Gesellschaft zur Förderung der Wissenschaften e.V. (DE) | 1999-08-12 | — | — | WO | disclosed |