Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR1A | P08908 | 9/20 | 0.42 |
| ▸ | DRD2 | P14416 | 3/20 | 0.36 |
| ▸ | HTR2A | P28223 | 2/20 | 0.36 |
| ▸ | DRD3 | P35462 | 2/20 | 0.36 |
| ▸ | ADRA1D | P25100 | 2/20 | 0.35 |
| ▸ | ADRA1A | P35348 | 2/20 | 0.35 |
| ▸ | ADRA1B | P35368 | 2/20 | 0.35 |
| ▸ | DRD1 | P21728 | 1/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.34 |
| ▸ | GLA | P06280 | 1/20 | 0.34 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.34 |
| ▸ | HPGD | P15428 | 1/20 | 0.34 |
| ▸ | CASP1 | P29466 | 1/20 | 0.34 |
| ▸ | CASP7 | P55210 | 1/20 | 0.34 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22410924 | 1.00 | HTR1A (0.42) | HTR1ADRD2HTR2ADRD3ADRA1D | |
| SCHEMBL6581590 | 0.83 | HTR1A (0.50) | HTR1ADRD2HTR2ADRD3ADRA1D | |
| SCHEMBL6585810 | 0.83 | DRD2 (0.40) | DRD2HTR2ADRD3 | |
| SCHEMBL6583915 | 0.81 | HTR1A (0.45) | HTR1ADRD2HTR2AADRA1DADRA1A | |
| SCHEMBL7480063 | 0.74 | HTR1A (0.50) | HTR1ADRD2ADRA1DADRA1AADRA1B | |
| SCHEMBL7483007 | 0.74 | HTR1A (0.50) | HTR1ADRD2ADRA1DADRA1AADRA1B | |
| SCHEMBL7480273 | 0.74 | HTR1A (0.50) | HTR1ADRD2ADRA1DADRA1AADRA1B | |
| SCHEMBL7480058 | 0.74 | HTR1A (0.50) | HTR1ADRD2ADRA1DADRA1AADRA1B | |
| SCHEMBL6583413 | 0.72 | ADRB1 (0.50) | HTR1AADRA1DADRA1AADRA1BALDH1A1 | |
| SCHEMBL6585688 | 0.72 | HTR1A (0.50) | HTR1AADRA1DADRA1AADRA1BALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0861837-B1 | 2-Aminoindane derivatives, process for their preparation and pharmaceutical compositions containing them | SERVIER LAB (FR) | 2004-04-28 | — | — | EP | claimed |
| EP-0861837-A1 | 2-Aminoindane derivatives, process for their preparation and pharmaceutical compositions containing them | ADIR ET COMPAGNIE (FR) | 1998-09-02 | — | — | EP | claimed |
| WO-2020183011-A1 | HTR1D INHIBITORS AND USES THEREOF IN THE TREATMENT OF CANCER | INSTITUT CURIE (FR) | 2020-09-17 | — | — | WO | disclosed |
| EP-0861837-B1 | 2-Aminoindane derivatives, process for their preparation and pharmaceutical compositions containing them | SERVIER LAB (FR) | 2004-04-28 | — | — | EP | disclosed |
| EP-0861837-A1 | 2-Aminoindane derivatives, process for their preparation and pharmaceutical compositions containing them | ADIR ET COMPAGNIE (FR) | 1998-09-02 | — | — | EP | disclosed |