Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP2A6 | P11509 | 5/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.34 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.34 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.34 |
| ▸ | CYP1B1 | Q16678 | 1/20 | 0.34 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.34 |
| ▸ | CYP1A2 | P05177 | 3/20 | 0.33 |
| ▸ | ERN1 | O75460 | 1/20 | 0.32 |
| ▸ | TRPM4 | Q8TD43 | 1/20 | 0.31 |
| ▸ | GPR84 | Q9NQS5 | 1/20 | 0.31 |
| ▸ | ESR1 | P03372 | 1/20 | 0.31 |
| ▸ | ESR2 | Q92731 | 1/20 | 0.31 |
| ▸ | FADS1 | O60427 | 1/20 | 0.31 |
| ▸ | MAPT | P10636 | 2/20 | 0.31 |
| ▸ | MEN1 | O00255 | 1/20 | 0.31 |
| ▸ | LMNA | P02545 | 1/20 | 0.31 |
| ▸ | POLB | P06746 | 1/20 | 0.31 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.31 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.31 |
| ▸ | ALPG | P10696 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2769437 | 0.77 | ERN1 (0.47) | CYP2A6ALDH1A1HSD17B10HIF1ACYP1B1 | |
| SCHEMBL6413875 | 0.77 | CYP2A6 (0.40) | CYP2A6ALDH1A1HSD17B10HIF1ACYP1B1 | |
| SCHEMBL251216 | 0.74 | RXRA (0.44) | CYP2A6ALDH1A1HSD17B10MEN1KMT2A | |
| SCHEMBL1389124 | 0.74 | RXRA (0.44) | CYP2A6ALDH1A1HSD17B10MEN1KMT2A | |
| SCHEMBL4767088 | 0.70 | CYP2A6 (0.44) | CYP2A6ALDH1A1HSD17B10HIF1ACYP1B1 | |
| SCHEMBL6646882 | 0.69 | ALDH1A1 (0.47) | ALDH1A1HSD17B10HIF1ACYP1B1L3MBTL1 | |
| SCHEMBL5024019 | 0.69 | CYP2A6 (0.54) | CYP2A6ALDH1A1HSD17B10HIF1ACYP1B1 | |
| SCHEMBL30366335 | 0.69 | CYP2A6 (0.54) | CYP2A6ALDH1A1HSD17B10HIF1ACYP1B1 | |
| SCHEMBL24361998 | 0.66 | CYP2A6 (0.44) | CYP2A6ALDH1A1HSD17B10HIF1ACYP1B1 | |
| SCHEMBL6416996 | 0.66 | CYP1A2 (0.61) | CYP2A6ALDH1A1HSD17B10HIF1ACYP1B1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1390354-A1 | TRIAZINYL ACRYLAMIDE DERIVATIVES AS KINASE INHIBITORS | Amgen Inc. (US) | 2004-02-25 | — | — | EP | disclosed |
| WO-2002083653-A1 | TRIAZINYL ACRYLAMIDE DERIVATIVES AS KINASE INHIBITORS | AMGEN INC. (US) | 2002-10-24 | — | — | WO | disclosed |