Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CA2 | P00918 | 19/20 | 0.67 |
| ▸ | CA1 | P00915 | 12/20 | 0.67 |
| ▸ | CA12 | O43570 | 9/20 | 0.67 |
| ▸ | CA9 | Q16790 | 9/20 | 0.67 |
| ▸ | CA4 | P22748 | 7/20 | 0.67 |
| ▸ | CA6 | P23280 | 4/20 | 0.67 |
| ▸ | CA5A | P35218 | 4/20 | 0.67 |
| ▸ | CA7 | P43166 | 4/20 | 0.67 |
| ▸ | CA14 | Q9ULX7 | 4/20 | 0.67 |
| ▸ | CA5B | Q9Y2D0 | 4/20 | 0.67 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.60 |
| ▸ | MAPT | P10636 | 1/20 | 0.57 |
| ▸ | MEN1 | O00255 | 1/20 | 0.53 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.53 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8506132 | 0.88 | CA2 (0.67) | CA2CA1CA12CA9CA4 | |
| SCHEMBL10431754 | 0.86 | CA2 (0.68) | CA2CA1CA12CA9CA4 | |
| SCHEMBL587389 | 0.82 | HTR6 (0.53) | CA2CA1CA12CA9CA4 | |
| SCHEMBL2304051 | 0.82 | CA2 (0.64) | CA2CA1CA12CA9CA4 | |
| SCHEMBL27609957 | 0.80 | ALDH1A1 (0.46) | CA2CA1CA12CA9CA4 | |
| SCHEMBL6063750 | 0.80 | CA2 (0.61) | CA2CA1CA12CA9CA4 | |
| SCHEMBL142107 | 0.80 | CA2 (1.00) | CA2CA1CA12CA9CA4 | |
| SCHEMBL1804221 | 0.80 | CA2 (0.69) | CA2CA1CA12CA9CA4 | |
| SCHEMBL11730795 | 0.80 | CA2 (0.69) | CA2CA1CA12CA9CA4 | |
| SCHEMBL6581495 | 0.78 | ENPP2 (0.46) | CA2CA1CA12CA9CA4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 13 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1112265-B1 | 2-ARYLALKYLTHIO -IMIDAZOLES, 2-ARYLALKENYL -THIO -IMIDAZOLES AND 2-ARYLALKINYL -THIO -IMIDAZOLES AS ANTI -INFLAMMATORY SUBSTANCES AND SUBSTANCES INHIBITING THE RELEASE OF CYTOKINE | MERCKLE GMBH (DE) | 2004-01-14 | — | — | EP | disclosed |
| US-6432988-B1 | RHEUMATIC DISEASES, (OSTEO)ARTHRITIS, CACHEXIA, INFLAMMATORY BOWEL DISEASE, TOXIC SHOCK SYNDROME, SEPSIS, CROHN*S DISEASE, PSORIASIS AND GOUT TREATMENT | MERCKLE GMBH (DE) | 2002-08-13 | — | — | US | disclosed |
| EP-1112265-A1 | 2-ARYLALKYLTHIO -IMIDAZOLES, 2-ARYLALKENYL -THIO -IMIDAZOLES AND 2-ARYLALKINYL -THIO -IMIDAZOLES AS ANTI -INFLAMMATORY SUBSTANCES AND SUBSTANCES INHIBITING THE RELEASE OF CYTOKINE | MERCKLE GMBH (DE) | 2001-07-04 | — | — | EP | disclosed |
| WO-2000017192-A1 | 2-ARYLALKYLTHIO -IMIDAZOLES, 2-ARYLALKENYL -THIO -IMIDAZOLES AND 2-ARYLALKINYL -THIO -IMIDAZOLES AS ANTI -INFLAMMATORY SUBSTANCES AND SUBSTANCES INHIBITING THE RELEASE OF CYTOKINE | MERCKLE GMBH (DE) | 2000-03-30 | — | — | WO | disclosed |
| EP-0505376-B1 | MUSCARINIC RECEPTOR ANTAGONISTS | PFIZER LTD (GB) | 1994-12-07 | — | — | EP | disclosed |
| US-5340831-A | Muscarinic receptor antagonists | PFIZER INC. (US) | 1994-08-23 | — | — | US | disclosed |
| EP-0233051-B1 | ANTIARRHYTHMIC AGENTS | Pfizer Limited (GB) | 1993-09-15 | — | — | EP | disclosed |
| EP-0505376-A1 | MUSCARINIC RECEPTOR ANTAGONISTS. | PFIZER LTD (GB) | 1992-09-30 | — | — | EP | disclosed |
| WO-1991009013-A1 | MUSCARINIC RECEPTOR ANTAGONISTS | PFIZER LIMITED (GB) | 1991-06-27 | — | — | WO | disclosed |
| US-4806536-A | Piperazinyl-substituted pyridine and imidazole anti-arrhythmic agents | PFIZER, INC. (US) | 1989-02-21 | — | — | US | disclosed |
| EP-0233051-A2 | Antiarrhythmic Agents | Pfizer Limited (GB) | 1987-08-19 | — | — | EP | disclosed |
| US-4017631-A | MICROBIOCIDES | JANSSEN PHARMACEUTICA N.V. (BE) | 1977-04-12 | — | — | US | disclosed |
| US-3991202-A | ANTIMICROBIALS | JANSSEN PHARMACEUTICA N.V. (BE) | 1976-11-09 | — | — | US | disclosed |