Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MMP2 | P08253 | 5/20 | 0.36 |
| ▸ | MMP9 | P14780 | 5/20 | 0.36 |
| ▸ | RAB9A | P51151 | 1/20 | 0.35 |
| ▸ | MAPT | P10636 | 1/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.34 |
| ▸ | POLB | P06746 | 1/20 | 0.34 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.34 |
| ▸ | MEN1 | O00255 | 1/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.34 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.34 |
| ▸ | GAA | P10253 | 1/20 | 0.33 |
| ▸ | HTT | P42858 | 1/20 | 0.33 |
| ▸ | TSHR | P16473 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6796974 | 0.90 | MMP2 (0.38) | MMP2MMP9RAB9AMAPTSMN1; SMN2 | |
| SCHEMBL6579690 | 0.80 | MAPT (0.33) | MMP2MMP9RAB9AMAPTSMN1; SMN2 | |
| SCHEMBL6213755 | 0.67 | GAA (0.40) | MMP2MMP9SMN1; SMN2POLBL3MBTL1 | |
| SCHEMBL1520733 | 0.66 | SIRT1 (0.45) | — | |
| SCHEMBL19926708 | 0.61 | ACHE (0.39) | POLBHSD17B10TSHRALDH1A1 | |
| SCHEMBL6582614 | 0.61 | MAPT (0.37) | MAPTPOLBMEN1KMT2AHSD17B10 | |
| SCHEMBL3030809 | 0.61 | TRPM5 (0.43) | SMN1; SMN2TSHRALDH1A1 | |
| SCHEMBL6797835 | 0.60 | OPRM1 (0.32) | MAPTSMN1; SMN2POLBMEN1KMT2A | |
| SCHEMBL6579693 | 0.60 | KMT2A (0.37) | MAPTSMN1; SMN2MEN1KMT2AHSD17B10 | |
| SCHEMBL547259 | 0.60 | SMN1; SMN2 (0.44) | MAPTSMN1; SMN2ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1146044-B1 | CNS active cyclobuta-indole carboxamide derivatives, processes for their preparation and pharmaceutical compositions containing them | SERVIER LAB (FR) | 2004-09-01 | — | — | EP | disclosed |
| EP-1146044-A1 | CNS active cyclobuta-indole carboxamide derivatives, processes for their preparation and pharmaceutical compositions containing them | ADIR ET COMPAGNIE (FR) | 2001-10-17 | — | — | EP | disclosed |